Honor and privilege to welcome you to the global event of the highly revised because of this incredible highly acclaimed bestselling book passing darwin. But until recently 100 people or a few more. Are some bad wine for now you can eat your favorite food from your refrigerator or the bedroom of choice on bed on beverage of choice and this is also being taped by cspans welcome everybody. These are unprecedented times and then and this moment in history where things could be shaped for ill or good in this we have found in our four weeks of telework is not really social distance it is geographic distance. We have galvanize the Global Community with that social interaction because we are all galvanized with our community and one of the biggest thinkers of the all and we will join the global conversation at the Atlantic Council we are concerned with covid19 for sure but looking at it the prism of friends and allies to shape the future looking between democracy and the uss role in the world and the future of the global system and looking importantly at Climate Change and that resilience factor in how we Harness Technology so in addition that jamie has a lot of titles but the Atlantic Council senior fellow has done a few other things as well. Leading technology in healthcare future Science Fiction novelist, faculty at the exponential medicine and with the human genome project last year appointed to the who Advisory Committee on human genome editing previously serving in the Security Council and the Senate ForeignRelations Committee and sometimes do things three or four. To keep up with bicycle riding and other things. Also a regular commentator on cnn. This is the fifth book and since it came back in hardback last year and writes with great clarity and a sense of urgency that we should all take to heart. And with that scientific moral complexities and to see the big picture. But if you only read one book on the future of the species if you can read them read all of them. You get the point if you havent already you should. So this is my pick for you. So this is like telemarketing but here you go. Sourcebooks makes this available today 4. 95 one third of the regular price before asking him to speak you want to introduce you to the other special guests speaking for ten minutes and then he will do the same and as many of you know one of the worlds greatest scientists we promise you the backdrop as a professor for Harvard Medical SchoolHealth Sciences and technology at harvard and the Massachusetts Institute of technology and director of the National Institutes of Health Center of genomic science and biology of the licenses where he oversees the directed evolution of molecules polymers and whole genomes to create new tools and applications and bio production of chemicals. 1984 to develop the first genome sequence which resulted in the first genome sequence to help initiate the human genome project and is just a delight to have you with us and then what she has heard and asked the first question for james and george to answer the former president professor at Harvard Business school and senior associate from online. Her new book will be released in august. After that then moderate the questionandanswer session based on questions raised by you on the facebook site anyone compose a question and then those that will rise to the top of the list we encourage you to post questions throughout the session. Entrepreneur and innovator. Chair of medicine for Singularity University and exponential medicine a program that explores rapidly developing technologies in biomedical and health care so with that what an incredible lineup jamie kick us off. It is an incredible honor this is my dream team and everyone on earth to join me in any event like this just the people that are on this call now so thank you into a great cohost and with those sourcebooks to say i love my publisher but i happen to be one at this crazy moment we feel a sense of sadness and morning there are meaningful people and things that are lost. That there is a lot of pain but but that there is a new world on so many levels that is being created and that is accelerating in incredible ways a new communities are forming and its hard to differentiate because so many things are happening with new types of collaborations its not like a snow day or a big storm to wait it out and then the sun comes out, its a fundamental change of our history and history of everything. And really our world i have one leg in the world of National Security and geopolitics and the year of the 9 11 attacks but really in 1941 with a huge battle ahead and is not clear if that battle will be one that there were leaders like fdr and churchill who came together to say what we are fighting for and then we can organize around building that world. And annette political world what is exciting about this moment that we are all coming together with a little piece of fdr we are doing things that other governments may have done to provide support and hope and encouragement and that is incredible because yes we have a virus that is supercharged with globalization but the networks we are using to address the crisis are also moving at the speed of globalization communities like this. Everybody is forming and reforming communities to solve these kinds of problems and the genome assistant others around the world are coming together to say how can we Work Together to solve this problem. With the genetics revolution and then the eugenics revolution the species has this ability to read and write the code of life and its incredible when you think of it just one species and almost a godlike power that we have imagined and now suddenly we start to have these powers. So with that power comes great responsibility to make sure the most cherished ethics and values guide the application of the most powerful technology in racing forward in three primary areas and to precision than predictive healthcare and life we are i may get a massive data set that means with the sophistication of the tools with that complexity of our biology so we are developing using incredible capabilities not just individually but even before birth and thats the way when you think about healthcare now we tend to think about it in the context of healthcare of interaction we dont have a disease genome or healthcare genome but a human genome so at least the potential to be the range of possibility and outside the realm of healthcare. It will get much bigger with those challenging issues like parenting. And with those technologies change not how we make babies but shift towards embryo screening and ivf. Coming out in august talking about this but also it will change ultimately over time the nature of the babies that we make so this is a profound conversation and it feels like this is a conversation about science then we wouldnt need to have the conversation if it was. Ultimately this is about ethics because no technologies come with their own builtin value system at least to the most significant application of those technologies since the hard version came out last april but that preliminary reference the crisper babies who were born but since then there are at least those that could be more we just dont know and after that experience the World Health Organization created the to be one of the 18 members of the commission we are working extremely hard what could be a framework how we could apply these very powerful technologies in a way that could minimize harms and other members of the commission are here and im invited to speak at the vatican and those that are participating but this is about the future of our species. With religious conservatives and various backgrounds. And were all in this together. The genetics revolution is intersecting with the coronavirus crisis. And with those genome in two weeks. And with that digital readout to understand the virus do you have computer models and then we can develop testing despite the diagnostic test this quickly but now with the rapid sequencing that was innovated to watch this genome mutate as it spreads around the world which is critically important my friend that Professor Harvard Business School is also on this call is working to bring together those from around the world the genetic patterns we can use to understand to this resistance to viral infection to make smart decisions to have that kind of knowledge. Maybe we can do it in one year some say two years. I was talking to a very smart scientist the other day in l. A. And said he didnt know if he one we could ever achieve this. And then those Surveillance System all of these tools are essential and with that incredible science and this comes at a very significant chant on challenges. How do we optimize the benefits. As long as we are living in that world where we could just make the smartest decisions possible we live in a world that is defined by politics certainly we see that in the political failure of china especially in the first three weeks of this outbreak to test and have adequate information to be provided to the American People i would say the failure of the who but all of us over decades to build the who to resource and empower and the mandate to do the job and then the science exist within the context of the global power structure between United States china and others. And then that we havent really gotten since sputnik this isnt just something for professors. Everybody needs to understand the science not just to understand the world around us but to make smart decisions to protect the people that we love. In 23 years ago working on the national Security Council in my good friend is also on this call was telling everybody and then to focus on terrorism. So this is just one little thing tragically with 9 11 the memo was on president george w. Bushs desk so to be effective we have to try to see whats coming around the corner so we have to get through this crisis what are the other big existential threats its not just coronavirus or deadly pathogens but those that pose existential harm imparts because we have organized yourselves around states and the International Organizations that are funded in a controlled from what needs to be done. What the book is trying to do was pull all those pieces together in a package for everybody. But this is the greatest story of all time. And the future of the species but in this revised paperback the first stories of the crisper babies and the the first stories of the crisper babies and the but then to understand my feeling there is a package of things to get what we are facing in each of these categories. I hope this is one. And then we have spoken about this to the Senior Scientist and the seventh and eighth graders in new jersey these issues are human issues so we have to be asking elected officials and government officials what are they doing. Once you deliver it it becomes everybody else owns it but i hope that whatever the digital equivalent is of marking up a book or ripping out pages and that just for today they are practically giving it away the official price 4. 75 but the amazon price just today is like 3. 50 but nobody knows in the history of the world ever made money off of writing books. You write them to share ideas and bring them together there is a lot of fear to hunker down in moments like this but the world is changing in such a huge and fundamental way that while we are doing that and then to take a step back to see the big picture that is what will i was to identify the norstar. The little decisions along the way based on the goal of where we would like to head. Everybody who sees the big picture of the science and then because of that was my friend George Church and that such an honor to have all of my people that most people believed i cant speak for other planets certainly among the most creative and thinking scientist and because of the woolly mammoth people have said the Charles Darwin they could be coincidence but judge for yourself. We would love for you to share your thoughts with these incredible tools and then to be used to address the crisis. It is truly an amazing time. And then to embrace the threat and with the remarkable things coming out. And the flu and the things that cause seizures. And that is the commitment with better medicine in the future. With that spiking collaboration with sars and a bola but finally be got it right. And then the diagnostics couldve saved us to trillion dollars spending tens of millions of dollars to think of what we can get Going Forward to be proactively. So on the topic of darwin to think about the biology of engineering life in general doesnt have to be dna or rna but far from the ancestors and this includes like therapies and diagnostics and then neutral pics like adderall or ritalin and doesnt mean they are bad but on the contrary that allows us but it is distracting to take six decades but we are seeing right now with covid19 is something that goes much faster. So what are we doing to be described broadly on the order of eight things of therapies and vaccines that are more diagnostic and that could take 18 months to deliver or more that is very fast which most take decades but it is frustrating for those of us who are locked down so in that they are the category and now they are adapted we know what receptors there are and the molecules that inhibits others viruses that can be adapted. Many of these have already been approved for Clinical Trials or use so the reuse makes a faster path. What weve already got in the pipeline that has been ingested into volunteers thank you to the medical volunteers and workers who are really on the front lines. And then take a moment to thank them. So to be tested with those viruses there is a phenomenon and then with those receptors so theres to make a risk are the next coronavirus that comes from nowhere we are developing life systems for testing new therapies so thats in the character on category of therapies and vaccines but. We see politicians in the same room and they are wearing masks. Whenever we go to the grocery store, and we take pictures and talking of how well we are queuing up for example, that is the talent challenge in the docs of how well were making progress on this, were developing rapid home test and rapid centralized test, these are getting down on a dollar or less per test and they can happen in five minutes and some of them can happen in more samples and more accurately than variations that occur. There are two things, viruses and logical reaction, you really could go back into the workplace and ideally you would want to be 0 positive and virus negative. Virus negative see can affect a phone number of viruses 1 10 and 0 positive low fault and positive and you can look like you have antibodies to coronavirus and these are the common cold coronavirus, third of the common cold, you want to have very specific test, when you start hearing more and more in the news about the 0 positives test, keep that in mind, then all of the above, all the vaccines and therapies and diagnostics have to be tested on a cohort we can share, one of these is a project which weve been working on since 2005, this is like wikipedia, this is your project, anybody can participate in see the data, if not sideload, i think this is a moment for that kind of project. We need to have diagnostics that are not just custom and spoke for the moment where we have the struggle like we lost in the United States shuffling around, even in the United States is not clear to have a high enough sensitivity, but any case, we need something where we can look in advance at all the things that are causing us respiratory distress in the Drug Resistance and so forth. So in addition to the custom, we need a more general standpoint. That is my list of what we can do and what we are doing and projects all over the world its wonderful to see it being shared, we have one last thing which is further off by getting getting we have a way to make any organism in nicely with jamies book, it is not going to solve our problem in the next couple of weeks, but is a very interesting thing that we can do a synthetic policy. So i look forward to the conversation that is coming up very soon. Thank you. Thank you both, so much, its given us a ton to think about, let me get things going by trying to pull this together and asking one question and then ill turn over to daniel. Jamie, i agree with a lot of what do you say, clearly were going through a moment of change, clearly everyone in the world needs to understand that the work that people are doing is crucial, science matters and we need to support it and try to understand the best we can, i also agree of course that assisted reproductive technologies are part of whats driving this change, that the baby businesses no longer and we are fundamentally changing the nature of conception and of life, however, but less sanguine about whats going to come out of this moment, yet a very lovely phrase starting out that people are taking over from government, that lacking in fdr at the moment, people are providing hope, support and encouragement, that is great. There are other things that governments usually provide things Like Research funding, and Economic Stability Fund and infrastructure, concern for inequity, concern for inequality and fundamentally ruled. All of these technologies are so pathbreaking, need some set of guidelines around them, some Financial Support and some concern with whos getting access and whos not, who is surviving the coronavirus and who is dying disproportionately. Where do the rules for the brave new world come from, can we as people actually