To order, i thank you very much and i apologize for being late. They take on a life of their own but i just want to say good morning, good morning doctor collins and welcome back. Let me just say thank you on behalf of the subcommittee for hosting members of the subcommittee for the nra campus last week. We had a wonderful opportunity to learn more about in ages work. We met with researchers who were working to develop treatment for major depression, shrink cancer tumors. We heard from participants whose lives have been changed back Clinical Trials. So it was a moving experience as well and we welcome our witnesses, including the five director said join as today and, in addition, doctor Francis Collins as john this is many times as director of National Health, today joined by dr. Bruce, director of the National Institute of biomedical imaging and bioengineering, Helene Langevin director of the National Director of health. Doctor eliseo perezstable, director of Minority Health and the sporty. Director Patricia Flatley brennan, pediatrician and director of National Library of medicine. And doctor christopher austin, director of advancing conditional scientists. Your work, all of the 27 institutes and centers needs to treatments and cures for diseases and conditions that affect people around the globe. It is transformative and some of the greatest good that we can do in government. Each year we hold a Budget Hearing to hear from the united director as well at directors of five or six of the institutes. Todays hearing is an opportunity for the subcommittee members to hear more and from directors of an additional five institutes and centers. Which was very important to all of us. Whether or not i joined the subcommittee a few years ago, and we used to invite every director to testify. It has been a long time since we have heard from many of them, so, in fact, im going to be plain spoken about this, and my mom Ranking Member, congressman cold knows about this. I wanted to include the National Institute of nursing, i want to include the National Center, and the National Eye Institute as well this morning. Unfortunately, the administration denied our request on the grounds that we did not provide a weeks notice. Im disappointed but, nevertheless, we will find another opportunity to hear from other directors. Again, i think we ought to be inviting every director at least every two or three years to be able to listen to what you are saying and how we can assist in that process. It is critical for the subcommittee to get a full picture of the nhl portfolio. The in h approved our quality of life and save lives. Im so glad that the congress increased the nih funding by nine billion dollars, or 30 . The subcommittee did this on a bipartisan basis. Over the last four years. The house bill increases funding for each of the institutes buy it 4 . Its a statement of our values and i reflect one of our commitment to invest and basic Biomedical Research at the end i watch. Its not overstating the case to say that the in h has prolonged every american. Because of this research we have childhood decrease cancer mortality by 50 in 35 years. We have a vaccine for cervical cancer, a drug that prevent hiv transmission with 99 effectiveness. In fact, a recent study in the proceedings of National Academy of Sciences Found that nih research contributed to every single one of 210 drugs between 2010 and 2016. That is your impact and it is amazing. So, to our guests, we say thank you to everything that you do, and we look forward to our conversation today, and let me turn this over to my colleague from oklahoma, the Ranking Member of the subcommittee. Im glad that weve had her back, she said the most excused absence of all time but it great to have her back. Ive already told the chair this. At some point i have to go to a Republican Leadership meeting, it has nothing to do with your testimony put up uncalled away and i want to congratulate our chair for scheduling a perfectly timed hearing because we need something to bring us together, and you guys do that so that, wonderful to see you. Today, we have our second Budget Hearing on the National Institute of health, and i want to thank the chair for having this hearing, inviting some of the institutes and centers, we did not get to hear from as often as we should, and i associate myself with remark to made about that. I look forward to learning about the research being done and the promise and cures of the future. I would be remiss if i did not recognize doctor collins, on reaching the accomplishment of reading that and i age four years. Hes the best politician in washington d. C. If he can get nominated by both president bomber and President Trump. A great deal of National Confidence in his ability that he has assembled there and has been there for many many years. Obviously, doctor collins as an advocate for groundbreaking research ive said it but the four years of sustained funding increase, what was very bipartisan owes a great deal to our confidence in doctor columns as the leader of this institute as well, and he has made the case up here for a lot of years as to why this is an important investment in a bipartisan fashion. I want to highlight some of the work being done through the support of the nih. I never says funded by the nih, so we need to work on that, maybe require that when they get grants. But working with colleagues at Oklahoma State university, researchers at the Oklahoma Medical Research foundation are using a novel threedimensional model to study the respite pretoria virus,s affecting belongs. It is a leading cause of pneumonia worldwide, and can take a particularly heavy toll on children, affecting more than half of their first year of life and 100 percent by 82,. The virus is highly contagious and for those with weakened i mean system from conditions like asthma, it can be dangerous and deadly. These researchers hope to reveal what predisposes infants to infection and create a launching pad for therapy down the line. This long in a petri dishes model could prove to be a valuable tool for studying, flew, allergies and asthma. Another area focuses lucas. Lupus affect up to 1 million americans but has a particularly chronic toll on African Americans, hispanic americans and native americans. Its an auto dummy indices, that with your own it mean system is responsible for the breakdown of its own cells. The information scene in the police can affect various organs and nobody, including the ones of joints, skin, and internal organs. The disease can be severe and lifethreatening, and cause permanent organ damage. Currently, there is no known cure. It remains a top ten cause of death in African American and Hispanic Women between the ages of 15 and 45, and you understand more about that, scientists are connecting largescale genetic analysis. It will focus on 25 seen that happen previously linked to the disease, the goal is to identify the genetic corporate that burden African Americans with lupus. The study built on the groundbreaking work at the Oklahoma Medical Research foundation in the lupus space, including the discovery by one of its own researchers, doctor judith james, it can delay the symptoms of lupus. These medications are now part of the standard treatment of care for many lupus patients. There are countless quarries like these and groundbreaking research taking place around the United States as a direct result of nih funding. A simple idea can open a new field of Biomedical Research. All americans benefit from this research, future generations will benefit, from the ultimate promises from the research being done today. Despite the controversy that can surround this bill, support for research at the in h has been broadened and bipartisan and supported by leadership in the house and senate alike. Recognizing all of the interview directors today because it rather hear from them. I want to think each of you and your colleagues and those institute and Center Leaders that are not with, us that our passioned, dedicated, and do hard work. I believe that the work will change the course of the Disease Detection and treatment for years to come. Thank you, madam chair for holding this hearing and i yield back my time. Thank you very much, a congressman coal. I would just say, im not going to into what they do, but im so proud that the yale school of medicine has one of the clinical and transitional science awards. They are a hub and its amazing work that gets down there as well. So we thank you for that, so let me yield to the chairman of the appropriations committee, my colleague congresswoman. And i think my chair of this Extraordinary Committee for this hearing, which is still very important. And i think, im sorry youre leaving, but i think my good friend mr. Coal for holding this hearing. Theres no question that whether its chairman coal or not chairman coal, there is bipartisan support for the outstanding work that you are doing and i really thank my good friend chairwoman the laurel for holding this hearing. And i welcome our exclaimed panelist and doctor collins. Ive been reading you with a big smile for many years, and i really appreciate all that you and your team do. Earlier in the year, however, the Trump Administration submitted a budget that it would cut the nih by 5 Million Dollars. It Crystal Clear that President Trump doesnt really understand the nature of this committee and how bipartisan it is. And no regard for the National Institutes of health and the cutting edge work that you do to save lives, and then skewers and improve the health of americans. Despite the president heartless and misinformed efforts to get the National Institute of health, we have responded resoundingly. Unlike the president , my colleagues and i prioritize the health of all americans. We are on track to invest billions more than the president would for our worldclass National Institutes of health. Our house past, fiscal year 2020, labor health and Human Services bill, that would provide two billion dollars more for the National Institute of health, including a critical across the board increase for all of the institutes and centers. This would allow the National Institute of health to respond to scientific breakthroughs that responded from outstanding Research Done at the institutes, such as those with us today. We have the distinct pleasure to hear from several institute directors, who are leading innovation and their respective fields, and theres so much innovation going on i dont know if he just threw the numbers of the institute in a hat to try to pick which ones are here today, but i really look forward to hearing your remarks, not only will we hear about the encouraging advances but also the exciting innovations that are just over the horizon. Were talking about lifesaving achievements that, with our continued commitment and investment could soon be on our doorstep thanks to the National Institutes of health. So, rest assured the administrations attempt to slash your budget will not stand. We remain committed to ensuring that you have the tools and the resources you need to deliver for the american people, so i really do want to thank you and i look forward to our discussion, so thank you all for everything that you do just to improve the lives. We will proceed to Opening Statements from the panel, with six Witnesses Today so we have asked you to please offer three minutes of opening remarks, im sorry to curtail the five minutes that we want to get it all in. Doctor collins, again, welcome. You know the drill, the full testimony will be entered into the record. You are now recognized for three minutes. Doctor . Collins good morning chairwoman rosa delauro, distinguished committee members, im Francis Collins, the director now for over ten years of the National Institutes of health. On behalf of nih, i will think the committee on your efforts on the funding bill that passed the house in june, we are really grateful for your ongoing in bipartisan support. We were very pleased to have a visit by some of you last week,. Today i am joined by the leaders of five of the National Institutes of health 25 centers. Director of National Center for advancing transitional sciences. Im always impatient for basic research discovered to be translated into ways of new ways of combatting disease. Treatments exist for only about 500. Addressing the gap requires translation or research, one of my first initiatives on upon becoming director was to ask congress to create in cats to create the process. Next up is next to me on my left and right. Their focus on innovation that advances medical research, a database that provides research to more than 5 million articles for biomedical journals, and another is Clinical Trials that of, the online catalog of trails, which is a Great Research to share, that where you can find the trails. Now, director of Complimentary Health, which just celebrated their 20th anniversary. It was you, this subcommittee that established the center and 1989, citing the need for more evidence on Complimentary Health practices. Next, let me introduce doctor eliseo perezstable, directive not National Institute on Minority Health and labor disparities. Its important to meet him for many reasons, including many asked about the critical issue of mortality. Also part of todays, its director of National Institute of biomedical imaging. They engaged new types of innovation to create a smaller, faster and, less expensive medical technology. Again i, thank you for the opportunity i hope this explains why im so excited to lead all our institutes and centers, working together to encourage this next generation of researchers, and i can assure you we will speed the path from discovery to health. Well be happy to entertain your questions. Thank you very much, doctor collins and for being so sustained. Unusual for me, i know. Now, let me just recognize you, your full testimony will be entered into the record. You are recognized for three womens. Thank you. Its an honor to represent the thousands across the country were developing Innovative New technologies to improve human health. Ive only been director for nine months but spent 30 years pioneering new optics acknowledges and pioneering at the university of california. We transform through the innovation of disease. We support Cutting Edge Research that can be applied to a broad range of Biomedical Health care problems by building strong partnerships with academia and every institute and center. Our programs lead to better faster and less costly ways to advance technologies from, blackboard, to bench top, to bedside. Nibib supports 1000 grants and four major areas computation Artificial Intelligence, engineered biology, sensing an imaging and it vance therapeutics. One of our most innovative and practical something platforms has been developed to address the problem of food allergies. We all know that eating out can be an anxious and lifethreatening challenge for millions of americans. Recognizing this widespread problem, research have developed a rapid point of Care Technology. It is small enough to fit on a key chain and contest for common allergens such as gluten, milk or thats at your table in less than ten minutes. Small personal Center Technologies are also helping drivethrough developments of new imaging platforms to help address the challenging problem of Breast Cancer detection aimlessly in without xrays. Researchers are using invisible light pulses that are one billion of a section in duration to create ultrasound vibrations deep inside breast tissue. A sandwich are detected by centers on the skin surface, 3d images of breast issues structure and tissue are formed. And the ways that Imaging Technologies have eliminated the practice of exploratory surgery, new technologies are revolutionizing brain surgery to be done wit