a pretty slowly slow progression and slow clinical slow follow up. they did it to our political options is interpreted options are not so much to find at first bronco dilation as a principle and second the inflammatory treatment by local stewards and if those drugs won't work any longer you can even go as far as putting the patient into some kind of lung transplant so which kind of patients the patients you would choose for that. we are looking for patients to get them the perspective for transplantation in in general the patients. are very very limited in their in their capacity your lung capacity their limit at the exercise test for example six minute walk test is very short and we're looking for patients round about sixty years and less. in most of the cases you don't have to