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Has said the talks will continue until wednesday but no further you can say whether or not that is the final deadline for these trade and security in negotiations and deep both sides have said they will keep talking up until the final minutes indeed coming out of downing street in the u. K. Today they say theyll talk as long as it takes so long as we think that it deal is to be done and they have admitted though that these talks really are going down to the wire and of course just to give you a sense of that british newspapers today one saying history has its eye on wrecks it say remains to be seen of course whether or not that deal can be done in the coming days but the public here among those that weve spoken to there is a sense of fatigue now as these negotiations drag on and on theyve been going on and in one form or another for years now take a listen to what people on the streets of had to say. Im not worried about it because we need to get something so detailed. We need to make it do. We dont have to give in to what we should but they want to be feels like its been buried in the public to know about this and whats going on it is buried among the town pandemic virus that he succumbed to 75 percent i dont know how many people realize break faith with anything i said to you mean this is what i would want to know deal situation and i dont like the fact that the government has made on what they promise i think is very unfair. People seem crazy i mean 2016 we would say than 4 years later and i have but i think if i didnt progress at all to be honest with you personally i think i would be over is probably better than a fair deal with just what the reasons are you have said all along. Who knows whats going to happen but i think even though you know to be honest with you. Now optimists will say that this is the last minute drama is all part of the political stances that was expected at the end point of this these negotiations both sides wanting to prove just how hard they fought for that respective audiences but as barbara said the news coming out of it negotiations has been good to me 01000 s. All saying that that the chances of a deal are at this point 5050 now both signs of said that they do want a deal but not at any cost oh i want to give you the last word what happens if they dont shake hands on it if they dont manage to reach an agreement by the deadline set. No deal on the business side of things people call this armageddon because it would mean that 40 years of free trade of the Free Exchange of goods people Money Services from the United Kingdom to the European Union back and forth will be ending overnight that is the main point terrorists will come into into play into play for instance for crowds coming from britain to the e. U. 10 percent for u. K. Lemm 40 percent which would kill the Business Model off a number of pitches farmers and so on and so for as transport would be sewn into kaos planes probably couldnt fly anymore and would need emergency agreements from both sides is so yes we will not look be looking forward to that day but in evidence of it will come the 1st of january when everything will change for the better or the worse 1st of january mark your calendars in brussels barbara maze all in london charlotte shell some pill ladies thank you for your continued coverage. And were going to turn our attention now back to germany where chancellor merkel is pushing for stricter lockdown measures saying existing restrictions wont be sufficient to get the country through the winter a partial lockdown has been in place for more than a month now it has slowed but not stopped the rise in case numbers and hospitals in some areas are working at the limit the german state of bavaria has already opted to tighten restrictions starting wednesday the variance will be asked to stay at home with only a few exceptions. Arts lets turn now to do a Political Correspondent assignment young who can tell us more about these remarkable remarks by the chancellor why she weighing in now with simon. Well i think its because concern is growing lay low the the infection numbers have remain stubbornly high despite this lockdown that weve had limited lockdown over the last 5 weeks they infections have have begun to drop a bit but not nearly far enough and some hospitals are saying theyre getting close to exhausting capacity with some reporting that theyve got 40 percent more intensive care beds in use for example than they had back in the spring when there was the last significant infection spikes so very worried shes saying you know we wont get through this merely by a hoping and she also says that the rules already agreed between the various german states to impose tougher regimes where infections went up theyre not being implemented she said you know cases so shes concerned thats why shes speaking out. Now German Authorities as youve reported earlier are planning on a relaxing some of the restrictions over the Holiday Season but you know judging by what you just reported it seems the writing is on the walk and they continue on that path. Well thats definitely the hope of the German Government they want to have christmas in some form they want to allow. Family gatherings even in a reduced form but theres real concern from the experts that those increased contacts will lead to increased infections and at the moment this debate is being sort of carried on in the form of the question should there be a meeting of top level politicians another one in the next few days to impose some kind of regime perhaps in the in tightening what happens before and immediately after christmas because as i say theres real worry across the board that the infections just arent coming down quickly enough Political Correspondent simon young reporting thank you. Lets take a look now at the latest developments in the coronavirus pandemic indias Serum Institute says it has applied for emergency use authorization of its core on a virus vaccine in India Britain says it will administer the 1st doses of the beyond tech Pfizer Vaccine on choose day care workers and seniors will be 1st in line and countries across europe are still struggling to bring down infection rates greece denmark and hungry have all announced theyre extending restrictions into the new year. When israel a socialist president Nicolas Maduro has hailed a gigantic election when that hands in control of the National Assembly and cements his position and power are those the socialists won almost 70 percent of the votes but turnout was just 31 percent after opposition parties called for a boycott International Observers have condemned the vote altogether the European Union said the election was not free or fair but as well the selfproclaimed acting president on where though as call the vote a fraud so soon for those who are scared of the people are the ones who commit fraud with madieu ruin his regime have lost the popular will get in the majority of us want change in venezuela dont be surprised if they try to advance the result in the coming days of december because this election has done them no good they know when they want to turn now or to ask her like or in the caucus who can tell us more about these latest developments oskar what will happen now. You know what we can expect now through moment noise another monsoon there are only official told to reject these elections and people can vote digitally from today up to the 12th of the summer when people can physically because the poll and there will be the demonstrations went on in terms of the government theres not no big surprise in these Election Results this is what we were expecting and for the this year they have mocked the throne interiors from entering her only does just. Serve as an argument to legitimize their take over parliament in january and talk to us about the opposition now how united is the opposition oh you know this is many factions because they are different political ideologies that just opposing right there are going to put them all in one walk there are socialist parties communist parties and right parties there are also movements and all of it will n. G. O. S that are opposing the growth mode so the only thing they all have in common is that they want the route and one has their own perspective on how to do it so its not easy to room and keep them together right now turnout was very low 31 percent what does this mean from adore and its allies. Well motherhood has allies are saying that was actually a good turn on their absolute compare that to the turnout in the vote in romania that was similar but that percentage is way higher than that what many people. Think it was because we saw that these polls were just very not many people were going to vote the opposition has said that theyre its close to 80 percent or absent of that same from voting so theyre going to use that in order to play with the National Assembly and its going to be an argument for their allies to say its legitimate and then they can enact laws starting next year now theres a growing humanitarian crisis and a fantasy what does mentor wind mean for people just struggling to survive well i was im sure there are some and intend to resolve the humanitarian crisis but there is also intensive politically capitalize any hope that is sentiments where theres at least a government is constantly on the ground are falling and we see it with the support that they received yesterday and the region is not too fond of International Organizations or n. G. O. S lets remember there are u. N. Reports accusations and a pending investigation on Human Rights Violations torture and arbitrary earth as an bishan that mother who is responsible for theres also rampant corruption that makes it difficult for aid to reach the people that really need it. Reporting from kind of 7 is about to thank you very much. Youre watching d. W. Neros stick with us up next the latest a coronavirus news in our covert 19th special. Bombs or thank you so much for spending part of your day ill be back at the top of the hour with the world headlines. The fight against the coronavirus 10 democrats. As the rate of infection in developing what does the latest research say. Information and context the coronavirus update. On t. W. Whats the secret to this classic. Music the sound. Or the story behind the music. Before the insurance reduced. Up. Beethovens 9th symphony for the world starts to simmer down on g. W. Using a u. V. Lamp to kill the corona virus thats just one light bulb moment in a multitude of responses to the 19th cologne was repurposed and Hand Sanitizer at the beginning of the pandemic the speed of innovation amid coronavirus could be a game changer experts say it could revolutionize Global Health care allowing us to come up with solutions that could change Health Care Delivery. They say necessity is the. The mother of invention the coronavirus pandemic has thrown that into stark relief from innovations enabling us to live with the realities of the virus to devices that make it say to action possible heres the story of 2 entrepreneurs who say a diagnosis is just a breath away. Rather than christoph and thomas wolfe have a vision they want to return some normality to this called in 1000 times for months the been working on a breath test that can identify the Novel Coronavirus theyre now confident it works. In august from a technical point of view this device can get to areas where normally only a dog can sniff things out. Leak a device thats almost as sensitive as a dogs noles the technique is similar to a breathalyzer for alcohol. This is a stimulus when what we have here is a sterile mouthpiece. And you take off the packaging and then what happens you blow into the mouthpiece and you just breathe. In there start up the brothers develop highly Sensitive Sensor Technology from a spectrum meters put industry and labs for a new type of diagnosis in real time in an automatic and we can see all sorts of things using breath analysis like whether a patient had coffee yesterday afternoon or not we can identify his Nutritional Status we can see different amino acids different fatty acids all of this from the breath breath as a direct window into the human body. The brothers believe it could recognize a cop in 19 other researchers also say breath analysis could work in principle to test for the corona virus. The challenge is to is to get the. Methods that youre an on the the way the equipment is used to chew on and the analytical technique of mice with verified biomarkers are reliable. Once weve proven that then you have a corrupted 19 breath test ready to go conventional swab tests are reliable but often only carried out when the infection has been there for a while and a result usually takes 2 days the breath test detects metabolic changes in breathing caused by the virus while it is not yet 100 percent reliable it does give an immediate result. The researchers believe that they will be able to deploy the tests as early as next summer in places like football stadiums. Passengers could also be tested at airports before check in the accuracy of the test is currently around 80 percent however the researchers are expecting efficiency to increase significantly in the meantime a lot of detailed work remains to be done. People are complicated and youre looking for a small signal in a snowstorm a blizzard of information. But weve weve found weve found the signals we think are helpful Young Christophe and thomas both originally developed their test for very different types of that gnosis one problem with a covered 1000 tests is that they have not yet been able to carry out studies on patients with the virus they are hoping for to go into the access to the processors access to resources to allow us to carry out a validation study on the site in a hospital or an Airport Test Center and with that it becomes very easy to determine whether this would be a way to bring back some normality to people. And allies could be a way to detect cov in 1000 infections much faster than before. Matthew harris joins us now hes a clinical senior lecturer in Public Health at the Imperial College london mathew so glad you can join us now youve written and the scientific journal nature about how the response to covered 19 has been distinguished by socalled frugal innovations what exactly does that mean well thank you through litigation really is the term that we give to the kind of innovation we see in the resource constraints situations of extraordinary time pressure or situations where we dont have the kind of resources that we normally like to have when we where we develop Health Care Innovations and the word frugal oftentimes is referred to as sort of cheap or good enough innovation but actually frugal innovation is health care of patients thats actually as effective as the kind of innovation you would normally see but just in a way that is far more affordable far more sustainable maybe with fewer sort of complexity or functionality but that gets the job and undercoat it of course weve seen around the world some extraordinary difficult situations at National Level in terms of exposing the fragilities in our Health Care Systems but also the real increase in healthcare demands and it really has necessitated a new type of innovating in innovating pace rapidly using resources that we just find around us so kind of improvising if you are. This is the kind of innovation that we call through innovation so its about reacting quickly using what you have but did how then examples of what a frugal innovation could be. Well absolutely in the early days of the covert response we saw insincerity helping countries and really interesting examples of frugal innovations so for example where there was a lack of personal protective equipment we saw a clinicians improvised the use of simple acetate sheets the kind of such as a shes that used to overhead projectors in the old days and by simply putting some holes in either side of the s. K. Sheeting threading some ribbon on either side of those became very effective face vices to protect not only the clinician but also the patients in front of them when they were interfacing and this was of course extremely cheap and actually very very effective since then baseball is a vote and become more sophisticated but it was a very good example of the frugal innovation at the time another good example of innovating at a pace was the construction of hospitals and on the 10 days in china actually eventually also in the u. K. Where im from we saw the construction or repurchasing at least of conference sentences into into intensive care units and hospitals also in very very short amounts of time as a sort of idea of repurchasing the resources you have but also very very quickly the characteristic of really innovation now that the crisis has focused minds and mobilize so much in terms of responses as youve told us there is also kind of dying down side to this kind of concentration of response to the crisis. Well i think the pope it obviously has recorded a deviation of resources from other health care to focus our attention on covert response and as a result some other areas have if you like suffered in terms of Research Going into the and also the Health Care Delivery the different clinical conditions i dont think theres a downside to frugal innovation and i think its been a really revealing how weve been able to develop such Effective Health care responses in a short period of time. Without spending on safety checks or effectiveness or clinical effectiveness or for the patients that we serve so i dont see a downside to through elimination which tends to be for fordable Healthcare Systems as long as the necessary checks and balances are in place to ensure the safety of those devices or technologies youve written that this kind of innovation could lead to a leveling in Global Health care equality what does that look like. What is the level in the sense that code has made us really reflect on the fragilities in the Health Systems even in the high Income Countries settings and its made us pay much more attention to the kind of innovations that arise from the low Income Countries its something weve been up eating for many years and what code is doing is making us pay more attention to settings that traditionally we havent really noticed in terms of Health Care Innovation thank you Matthew Harris there talking about putting Human Resource lowness at the center of our cove in 1000 response is a clinical senior lecturer and Public Health at Imperial College london thank you for your insights. And now its time for one of your son and questions about the coronavirus our science correspondent Derek Williams is ready with an answer. Taking into account to patients sex and age what do the statistics say about complications. One of the clearest pieces of information thats come out of the statistics is that from the age of about 40 on women in general are a lot less likely than men to have severe Outcomes Data from both the c. D. C. And the European Center for disease prevention and control a reveal how stark the difference is this graphic for example emphasizes how much more likely men of a certain age are to end up in the hospital or the i. C. U. Numbers of men are represented by the blue bar and a numbers of women by the red one in europe men between 40 and 80 make up around 3 quarters of all intensive care cases and recorded deaths after 80 the split is more even but thats almost certainly due to the simple fact that a lot fewer men lived at that age so statistically the chances are a lot higher that in the over eightys a woman is going to get coke at 19 been a man is going to get it theres a lot of speculation about why and there and there doesnt seem to be a single reason that accounts for all of the discrepancy im several factors are likely playing roles we know though that people who have diabetes or high Blood Pressure or Heart Disease are at greater risk of severe outcomes if they contract covert 19 and aging men are more likely to have those comorbidities than aging women are but another possible contributing factor involves immune response the male and female immune systems. Different experts say because on their 2nd x. Chromosome women have another copy of many of the genes that are involved in fighting off disease its been theorized thats also why women are more likely to develop certain auto immune diseases than men but in this case it could be helping them keep covert 19 or its medical ramifications more effectively a bad thats hard to prove though. And thats all from us thank you very much for watching and stay safe. What secrets lie behind small. Discover new adventures in 360 degree. And explore fascinating World Heritage sites that. Dont. World heritage 316 getting out. That 77 percent. Are younger than. Me and me. And you know what time. Of the 77 percent. 77 percent this weekend on d w. This is. Coming up on the program is that. Its a big deal mollies transitional council. To lead the country into civilian. Also coming up. On the next president. Should think. Football in times of 19 and that makes it a bit more complicated than normal rules from

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