Exact Sciences prepares to open Rochester site in One Discovery Square Wisconsin-based Exact Sciences, which makes the colorectal cancer test called Cologuard, has filed building permits for a new Rochester site on the second floor of One Discovery Square, 202 Fourth St. SW. 8:01 pm, Feb. 10, 2021 × Wisconsin-based Exact Sciences, which makes the colorectal cancer test called Cologuard, filed building permits for its new Rochester site on the second floor of One Discovery Square at 202 Fourth St. SW. Building permits filed this week show Exact Sciences is preparing Suite 204 in the 89,000-square-foot complex. Exact is sandwiched between spaces occupied by Mayo Clinic and Boston Scientific. From M.A. Mortenson Co. materials