E-Mail CAMBRIDGE, MA--December 16, 2020--In 2019, the National Academies of Science, Engineering, and Medicine (NASEM) published a consensus report for the US Congress--Reproducibility and Replicability in Science--which addressed a major methodological crisis in the sciences: The fact that many experiments and results are difficult or impossible to reproduce. The conversation about this report and this vital topic continues in a special, twelve-article feature in issue 2:4 of the Growing awareness of the replication crisis has rocked the fields of medicine and psychology, in particular, where famous experiments and influential findings have been cast into doubt. But these issues affect researchers in a wide range of disciplines--from economics to particle physics to climate science--and addressing them requires an interdisciplinary approach.