HKU scientists develop a new chemical tool that sheds light

HKU scientists develop a new chemical tool that sheds light on how proteins recognise and interact with each other


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A research group led by Professor Xiang David LI from the Research Division for Chemistry and the Department of Chemistry, The University of Hong Kong, has developed a novel chemical tool for elucidating protein interaction networks in cells. This tool not only facilitates the identification of a protein’s interacting partners in the complex cellular context, but also simultaneously allows the ‘visualisation’ of these protein-protein interactions. The findings were recently published in the prestigious scientific journal Molecular Cell.
In the human body, proteins interact with each other to cooperatively regulate essentially every biological process ranging from gene expression and signal transduction, to immune response. As a result, dysregulated protein interactions often lead to human diseases, such as cancer and Alzheimer’s disease. In modern biology, it is important to comprehensively understand protein interaction networks, which has implications in disease diagnosis and can facilitate the development of treatments.

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Xiang David , Department Of Chemistry , Research Division For Chemistry , University Of Hong Kong , Professor Xiang David , Research Division , Hong Kong , Molecular Cell , துறை ஆஃப் வேதியியல் , ஆராய்ச்சி பிரிவு க்கு வேதியியல் , பல்கலைக்கழகம் ஆஃப் ஹாங் காங் , ஆராய்ச்சி பிரிவு , ஹாங் காங் , மூலக்கூறு செல் ,

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