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HKU researchers identify promising new biologics for obesity-related diseases

HKU researchers identify promising new biologics for obesity-related diseases
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United States , Department Of Chemistry , Journal Of The American Chemical Society , Research Division For Chemistry , University Of Hong Kong , Department Of Pharmacology , Hong Kong , Professor Xuechen , Research Division , American Chemical , Professor Wang , ஒன்றுபட்டது மாநிலங்களில் , துறை ஆஃப் வேதியியல் , இதழ் ஆஃப் தி அமெரிக்கன் இரசாயன சமூகம் , ஆராய்ச்சி பிரிவு க்கு வேதியியல் , பல்கலைக்கழகம் ஆஃப் ஹாங் காங் , துறை ஆஃப் மருந்தியல் , ஹாங் காங் , ஆராய்ச்சி பிரிவு , அமெரிக்கன் இரசாயன , ப்ரொஃபெஸர் வாங் ,

Researchers identify promising new biologics for obesity-related diseases

Researchers identify promising new biologics for obesity-related diseases
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United States , Mr Hongxiang Wu Research Division For Chemistry , Professor Xuechen Li Research Division For Chemistry , University Of Hong Kong , Department Of Pharmacology , Mr Yuanxin Li Department Of Pharmacology , Department Of Chemistry , Journal Of The American Chemical Society , Research Division For Chemistry , Research Division , Professor Xuechen , Hong Kong , American Chemical , Professor Wang , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் ஹாங் காங் , துறை ஆஃப் மருந்தியல் , துறை ஆஃப் வேதியியல் , இதழ் ஆஃப் தி அமெரிக்கன் இரசாயன சமூகம் , ஆராய்ச்சி பிரிவு க்கு வேதியியல் , ஆராய்ச்சி பிரிவு , ஹாங் காங் , அமெரிக்கன் இரசாயன , ப்ரொஃபெஸர் வாங் ,

New chemical tool that sheds light on how proteins recognise and interact with each other

New chemical tool that sheds light on how proteins recognise and interact with each other
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Xiang David Li , Xiang David , Department Of Chemistry , Research Division For Chemistry , University Of Hong Kong , Professor Xiang David , Research Division , Hong Kong , Molecular Cell , துறை ஆஃப் வேதியியல் , ஆராய்ச்சி பிரிவு க்கு வேதியியல் , பல்கலைக்கழகம் ஆஃப் ஹாங் காங் , ஆராய்ச்சி பிரிவு , ஹாங் காங் , மூலக்கூறு செல் ,

HKU scientists develop a new chemical tool that sheds light on how proteins recognise and interact with each other

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A research group led by Professor Xiang David LI from the Research Division for Chemistry and the Department of Chemistry, The University of Hong Kong, has developed a novel chemical tool for elucidating protein interaction networks in cells. This tool not only facilitates the identification of a protein’s interacting partners in the complex cellular context, but also simultaneously allows the ‘visualisation’ of these protein-protein interactions. The findings were recently published in the prestigious scientific journal Molecular Cell.
In the human body, proteins interact with each other to cooperatively regulate essentially every biological process ranging from gene expression and signal transduction, to immune response. As a result, dysregulated protein interactions often lead to human diseases, such as cancer and Alzheimer’s disease. In modern biology, it is important to comprehensively understand protein interaction networks, which has implications in di ....

Xiang David , Department Of Chemistry , Research Division For Chemistry , University Of Hong Kong , Professor Xiang David , Research Division , Hong Kong , Molecular Cell , துறை ஆஃப் வேதியியல் , ஆராய்ச்சி பிரிவு க்கு வேதியியல் , பல்கலைக்கழகம் ஆஃப் ஹாங் காங் , ஆராய்ச்சி பிரிவு , ஹாங் காங் , மூலக்கூறு செல் ,

HKU chemists develop a new drug discovery strategy for

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IMAGE: Graphic illustration of the work: DNA-programmed affinity labelling (DPAL) enables the direct screening of DNA-encoded chemical libraries (DELs) against membrane protein targets on live cells to create novel drug discovery.
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Credit: The University of Hong Kong
A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells.
Membrane proteins play important roles in biology, and many of them are high-value targets that are being intensively pursued in the pharmaceutical industry. The method developed by Dr Li s team provides an efficient way to discover novel ligands and inhibitors against membrane proteins, which rema ....

Hong Kong , Xiaoyu Li , University Of Hong Kong , Hong Kong General , Bryan Cao , Yiran Huang , Yizhou Li , Professor Of Research Division For Chemistry , Second Military Medical University , Centre For Panoromic Sciences , National Natural Science Foundation Of China , Nature Research Chemistry Community , Laboratory For Synthetic Chemistry , Nature Publishing Group , Technology Commission Of Hong Kong , Research Grants Council Of Hong Kong , School Of Pharmacy , School Of Pharmaceutical Sciences , Key Laboratory Of Synthetic Chemistry , Research Division For Chemistry , Research Division , Professor Yizhou , Pharmaceutical Sciences , Chongqing University , Professor Yan , Nature Chemistry ,