E-Mail IMAGE: (Left up panel) Effect of biosynthetic gene cluster muf or mutanofactin-697 (5) on biofilm formation on the surface of artificial acryl teeth. (Left bottom panel) Proposed biosynthetic pathway for mutanofactin-697... view more Credit: HKUST An inter-disciplinary team of researchers led by Prof. Qian Peiyuan, Chair Professor at the Hong Kong University of Science and Technology (HKUST)'s Department of Ocean Science and Division of Life Science has unraveled how a novel microbial small molecule released by Streptococcus mutans (S. mutans) - a bacterium commonly found in the human oral cavity - is connected to dental caries development using a synthetic biology approach, offering new insights to the health impact of the human oral microbiota and facilitating future research on the prevention of tooth decay. The research findings were recently published in the prestigious scientific journal