Hotel Ca' di Dio, Venice's Only 5-Star Hotel to Open in 2021 January 8, 2021 Venice's newest 5-star hotel, Ca' di Dio, will be born in May 2021. The hotel sits within a transformed ecclesiastical compound dating from 1272 that has hosted Crusaders, pilgrims and tourists for more than eight centuries. Located on the Riva Ca' di Dio, the hotel overlooks Venice's legendary lagoon, and is located adjacent to the Arsenale and the gardens that house the city's Biennale, one of the world's most iconic art festivals and exhibitions. The Ca' di Dio is an easy stroll along the waterfront from bustling St. Mark's Square.