How I’d invest £20k in a 2021 Stocks and Shares ISA Image source: Getty Images I’m encouraged by the current investment environment and I think 2021 is set to be an excellent year to invest in a Stocks and Shares ISA. The rollout of Covid vaccines has begun and the beginning of the end of the pandemic is in sight. Although it could take many months to vaccinate enough of the population to suppress the virus, stock markets may try to look forward and anticipate the reopening of economies. But I reckon the Stocks and Shares ISA winners of 2020 may not be the leaders in 2021. The stock market crash in March reversed aggressively and quickly in some sectors. For example, the technology sector benefited from work-from-home orders. By contrast, the travel & leisure sector suffered significant losses in 2020 as hospitality venues were forced to temporarily close. Stocks in depressed sectors could bounce back hard in 2021, in my opinion.