A surge in the pandemic has forced the pharma industry to deliver a wide-spectrum vaccine to fight mutation-prone SARS-CoV-2, pledging to prevent future outbreaks. In order to gain a competitive position in the market, vaccine manufacturers are investing in advanced platform technologies. The most extensive vaccination campaign in history is providing prophylactic results by delivering more than 12 billion doses of the COVID-19 vaccine, protecting 60 per cent of the global population as of June 2022. Now the next-generation COVID-19 vaccine is countering the challenge to enhance the immune response of their vaccine candidate to tackle the emerging COVID-19 variants. It is therefore imperative to remain vigilant and upgrade vaccine candidates to emerging sublineages of the virus. Let's take a closer look at some of these leading vaccines that are approved as broad spectrum virucide inhibitors.