The arrival of cannabis in Colorado since legalization in 2012 has helped foster a more open, honest dialogue surrounding the potential of THC and CBD. While there is still much to unearth regarding marijuana, legalization in Colorado has enabled the substance to overcome many of its most damaging misconceptions. Therefore, to truly understand cannabis, it is important to start at the heart of the plant. There is a lot of science behind cannabis that unfortunately makes the subject convoluted, especially when experts start using jargon like âhempâ and âCannabidiolâ. In reality, most newcomers to cannabis can receive a crash course on marijuana basics without diving deep into the science. A good starting point is to understand the primary differences between THC and CBD. Doing so will allow the consumer, to determine which compound is more appropriate for their situation.