New method offers insights into tension-sensitivity of potas

New method offers insights into tension-sensitivity of potassium channels


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IMAGE: The scientists formed a simple lipid bilayer by docking two monolayer-lined water bubbles and evaluated membrane tension based on the Young-Laplace principle to measure intra-bubble pressures lower than 100 pascals,...
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Credit: Masayuki Iwamoto from University of Fukui
Ion channels play an indispensable role in cellular physiology, and understanding the physical features that affect ion channel functions is a matter of considerable interest to biologists. Given that mechanosensitivity is an intrinsic feature of cells, the complex set of mechanical stresses acting on a cell at any time represents an important consideration in the field of cellular physiology. In fact, stretching forces created by mechanical stress are sometimes necessary to activate ion channels. As Professor Masayuki Iwamoto and Professor Shigetoshi Oiki of the University of Fukui explain, "Mechanical stresses change the level of cell membrane tension, and stretch-activated ion channels in the membrane mediate tension-related electrical transduction".

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Japan , Shigetoshi Oiki , Masayuki Iwamoto , Biomedical Imaging Research Center , Faculty Of Medical Sciences , University Of Fukui , Division Of Molecular Neuroscience , Professor Masayuki Iwamoto , Professor Shigetoshi Oiki , Professors Iwamoto , Specially Appointed , Fukui Faculty , Medical Sciences , Molecular Neuroscience , ஜப்பான் , உயிர் மருத்துவ இமேஜிங் ஆராய்ச்சி மையம் , ஆசிரிய ஆஃப் மருத்துவ அறிவியல் , பல்கலைக்கழகம் ஆஃப் ஃப்யூக்யூயீ , சிறப்பாக நியமிக்கப்பட்ட , ஃப்யூக்யூயீ ஆசிரிய , மருத்துவ அறிவியல் , மூலக்கூறு நரம்பியல் ,

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