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Therapy Using Dual Immune System Cells Effectively Controls Neuroblastoma

Therapy Using Dual Immune System Cells Effectively Controls Neuroblastoma
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United States , North Carolina , Elisa Landoni , Yang Xu , Xin Zhou , Chuang Sun , Yuhui Chen , Barbara Savoldo , Koichi Hirabayashi , Lung Cancer Initiative Of North Carolina , School Of Medicine , Bellicum Pharmaceuticals , Department Of Defense United States , National Cancer Institute , Immunology Program , Biomedical Imaging Research Center , Lineberger Comprehensive Cancer Center , Microscopy Services Laboratory At Department Of Pathology , Lineberger Immunotherapy Program , Laboratory Medicine , School Of Medicine Department Microbiology , Cancer Center Core , Comprehensive Cancer , Gianpietro Dotti , Medicine Department , Peishun Shou ,

New method offers insights into tension-sensitivity of potassium channels

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IMAGE: The scientists formed a simple lipid bilayer by docking two monolayer-lined water bubbles and evaluated membrane tension based on the Young-Laplace principle to measure intra-bubble pressures lower than 100 pascals,.
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Credit: Masayuki Iwamoto from University of Fukui
Ion channels play an indispensable role in cellular physiology, and understanding the physical features that affect ion channel functions is a matter of considerable interest to biologists. Given that mechanosensitivity is an intrinsic feature of cells, the complex set of mechanical stresses acting on a cell at any time represents an important consideration in the field of cellular physiology. In fact, stretching forces created by mechanical stress are sometimes necessary to activate ion channels. As Professor Masayuki Iwamoto and Professor Shigetoshi Oiki of the University of Fukui explain, Mechanical stresses change the level of cell membrane tension, and stretch-a ....

Shigetoshi Oiki , Masayuki Iwamoto , Biomedical Imaging Research Center , Faculty Of Medical Sciences , University Of Fukui , Division Of Molecular Neuroscience , Professor Masayuki Iwamoto , Professor Shigetoshi Oiki , Professors Iwamoto , Specially Appointed , Fukui Faculty , Medical Sciences , Molecular Neuroscience , உயிர் மருத்துவ இமேஜிங் ஆராய்ச்சி மையம் , ஆசிரிய ஆஃப் மருத்துவ அறிவியல் , பல்கலைக்கழகம் ஆஃப் ஃப்யூக்யூயீ , சிறப்பாக நியமிக்கப்பட்ட , ஃப்யூக்யூயீ ஆசிரிய , மருத்துவ அறிவியல் , மூலக்கூறு நரம்பியல் ,

New study challenges 'established' mechanism about selectivity of cellular ion channels

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IMAGE: Cell membranes contain channels that selectively permit ions to move into or out of the cell. In a recently published paper, researchers from the University of Fukui and Kanazawa University.
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Credit: University of Fukui
The cell membranes of all organisms contain ion channels that permit ions to pass into or out of the cell, and these channels play extremely important roles in fundamental physiological processes such as heartbeats and the rapid conduction of signals along neurons. An important property of these ion channels is their selective conductivity they selectively permit the passage of particular ions. For example, potassium channels more readily permit the passage of potassium ions than the passage of sodium ions, despite the fact that potassium ions are larger. ....

United States , Shigetoshi Oiki , Mika Hayashi , Bunkyo Fukui , Hiroe Yoneda , Scientific Research , Kanazawa University , University Of Fukui , Biomedical Imaging Research Center , Public Affairs , Nano Life Science Institute , Nano Life Science Institute Kanazawa University , Professor Shigetoshi Oiki , National Academy , Conductance Selectivity , Tortuous Trajectory , Long Residency Time , Specially Appointed , Fukui Faculty , Medical Sciences , Life Science Institute , Cell Biology , Molecular Biology , Chemistry Physics Materials Sciences , Biomechanics Biophysics , Research Development ,