Bioprocess researchers undertaking high-density mammalian, bacterial, or microbial cell culture separations can now benefit from a next-generation single-use, sterilized, closed-system BioProcess Container (BPC) designed to offer a highly efficient alternative for harvesting by centrifugation. The CentriPAK BPC, developed specifically for use with the Thermo Fisher Scientific Sorvall BIOS 16 centrifuge, enables optimal protection of critical sterile liquids from cross-contamination typically associated with reusable containers. The CentriPAK can be used to process culture volumes of between 3 L and 500 L, facilitating high-throughput and high-efficiency cell biomass or clarified supernatant harvesting to maximize laboratory productivity. Furthermore, there are no time-consuming, labor-intensive, and costly preparation and post-use cleaning steps involved. To ensure it meets the high standards expected in the bioprocessing industry, the unit is subject to thorough quality-control procedures, in compliance with current good manufacturing practice and ISO 13485:2016. The CentriPAK is available in various configurations and comes with a full suite of accessories, including adapters, racks, clips, and spacers.