Date Time New targeted agent achieves impressive response rate in trial with patients with uterine serous carcinoma In its first clinical trial in patients with a hard-to-treat form of uterine cancer, a targeted drug that subjects tumor cells to staggering levels of DNA damage caused tumors to shrink in nearly one-third of patients, investigators at Dana-Farber Cancer Institute reported. The results of a phase 2 study published today in the Journal of Clinical Oncology showed that a WEE1-directed therapy in uterine serous carcinoma (USC), which accounts for about 10% of uterine cancers but up to 40% of deaths from the disease, demonstrated strong and durable activity.