We need to redesign institutions to be proactive, agile, and socially just when confronted with compound risks that have become increasingly likely. Image credit: Dave Cutler (artist). Because the coronavirus disease 2019 (COVID-19) emergency is a protracted crisis that entails waves of infections over several months, the pandemic will inevitably continue to collide with other social and environmental shocks and disruptions, leading to increased risk of compound disasters (1). Globally, we have seen both extended and acute periods of stress on social and government systems driven by the COVID-19 pandemic as well as other natural and social hazards. When coupled with economic shocks, political fragility, and conflicts, these multiple stressors become concurrent drivers of complex emergencies that severely challenge domestic and international emergency response. Such crises present a need to better understand compound risks and prioritize collaborative action—we need to address neglected risk assessment challenges around communication, funding, governance, and social justice (2).