1. In this randomized controlled trial, prophylactic antibiotics resulted in significantly lower rates of first-occurrence urinary tract infections (UTIs) in infants with vesicoureteral reflux. 2. The groups did not differ in kidney scarring, kidney filtration function, or hospitalization rates due to UTI. Evidence Rating Level: 1 (Excellent) Study Rundown: Infants with vesicoureteral reflux are at