Research shows a promising alternative to personalized deep brain stimulation Millions of patients suffering from neurological and mental disorders such as depression, addiction, and chronic pain are treatment-resistant. In fact, about 30% of all major depression patients do not respond at all to any medication or psychotherapy. Simply put, many traditional forms of treatment for these disorders may have reached their limit. Where do we go from here? Research to be published in Nature Biomedical Engineering led by Maryam Shanechi, the Andrew and Erna Viterbi Early Career Chair in electrical and computer engineering at the USC Viterbi School of Engineering, paves the way for a promising alternative: personalized deep brain stimulation.