Words all in all we no longer know what were walking in till they cant see march. What she needs to break she will get about it back. To shes possible. So. Do no harm and shattered by the old tore it up going. To miss an episode we explore the ignorance and greed that led to our Current Crisis one of the 1st. Medicine is do no harm. Said that hypocrisy is was the 1st to say this and what that means is that the cure for any medical problem shouldnt be worse than the disease that youre trying to treat big chunk of america is in chronic pain and pain meds back pain pain arthritis events real and it affects peoples lives and they would like a way to live their lives to take care of their families without being in this name what the brain is trained is that different brains in their brain thats not in pain people have it in their hear theres a feel for some. Whatever mountain iranians or something out there is going to you know there was this new girl gets eliminated all your brain inside the company and the drug came out they received so many letters from people who had been suffering for years with no relief who finally felt like through oxycontin they were getting to be alive again in a way they hadnt for years and that they considered a miracle drug is the best thing that happened to me if i wasnt on this medication i just wouldnt be able to do the things that im doing now theres no question the best strongest and most of the opioids have serious medical side effects patients are just a. T. M. Machines some more you go back to the patient or you push buttons the more profit you can do the pharmaceutical companies all so were not entirely transparent about the addictive effect about the light and that peers were told they were nonaddictive when in fact they were and we dont get taught in medical schools. About illnesses that we and use we only get told about illnesses that were supposed to cure we also grew up thinking that doctors are always right so if you have a prescription its easy and we talk about opioid painkillers we are centrally talking about heroin tells the Drug Companies that its what i tell. Are the pushers and the pharmacists are the suppliers and thats how the a. D. C. Theres not a city in the United States right now that doesnt have a major opiate addiction problem and its not just in cities its in rural areas in fact in some places its worse in rural areas than anywhere else at the peak of the epidemic millions of people in the United States were prescribed 259000000. 00 prescriptions of opioids that means on average every adult is on one opiate you know once or twice a year if not more scares the living crap out of me opioids are a major category of medical spending according to the centers for Disease Control its about. 24000000000. 00 in direct cost for the medications and other 75000000000. 00 in Health Care Costs people are doing and oxycontin 8010. 00 pack a day thats a 1000. 00 worth of medication to kids who are spending hundreds of dollars a day if not thousands. Of her own walking. And its cheap. Really cheap really inexpensive readily available the shame of addiction keeps us from knowing the actual numbers but at least 2000000 americans and probably millions more are addicted to prescription opioids prescription drugs. Causing more deaths for example than Car Accidents from 1999 to 2070 over 500000 americans have died from an opioid overdose. More than all the americans killed on the battlefield since world war 2. Only to have. Been raped and form. Of children winding up in the foster care system because their parents are addicted kids growing up without parents parents who have lost children you have families decimated you have talents destroyed think that it started off with company in stanford connecticut that had some marketing material this is the worst manmade epidemic in the history of. American medicine its very clear when one looks at the overprescribing of opioids thats led to this Public Health crisis that the medical community really forgot the 1st rule which is do no harm. Opioids are among the worlds oldest known drugs there are medical religious and Recreational Use predates recorded history. These are really drugs such as opium codeine and morphine works directed from poppy flowers and its some kind of mystery of nature why did the poppy play out create morphine it can bind to the d opioid receptors in human brains and probably thats a mystery of nature will never be able to answer but that is the case because its chemically similar to that of compounds that are on brain makes an 874. 00 an english chemist by mixing morphine and other assets created a powerful opioid that was eventually called die a seal morphine nothing much resulted from his discovery 23 years later a german chemist working for what is now the bayer pharmaceutical corporation created the same substance baier quickly promoted the drug is less dangerous than morphine as well as a cough suppressant because of the heroic feelings recipients experienced they called it heroin heroin is a very slight. Chemical manipulation of the morphine molecule makes the compound heroin much more fat soluble the brain is mostly fat so if someone is exposed to heroin it gets into the brain many many times faster than morphine would the more route that a drug gets to the break we were told in humans no more apt its to cause a high this heroic drug originally promoted as a cough suppressant and for other common conditions were soon diverted and abused in 1904 the United States congress banned heroin declaring it a dangerous addictive illegal narcotic it probably would take too long for me to. Provide a theory of why as americans we have. Such love affairs with with drugs that potentially can kill us opioid addiction led doctors to fear its use for anything but short term richard pain or end of life Palliative Care that was a time when the medical community did understand that opioids needed to be prescribed. There obviously important medicines for easing suffering at the end of life they play an Important Role when used on a short term basis for severe acute pain for example after major surgery ventral the sciences started creating new semi synthetic opioids similar to heroin in 1017 oxy code was one of several semi synthetic opioids developed in germany you literally start with opium to make hydrocodone and oxycodone and the effects that hydrocodone oxy co dont produce in the brain are indistinguishable from the effects produced by heroin if you give an experienced heroin user oxy code to own and heroin its hard for that heroin user to tell which is which in fact if you ask them which they like a little bit better and unlike a blind taste test. Which was the study that has Columbia University the oxy codell and is preferred to the heroin so what im saying is that when we talk about opioid Pain Medicine worse since they talking about heroin tells in 1902 doctors John Purdue Gray and George Frederick bingham started the per do Frederick Company on manhattans Lower East Side and 1952 it was sold to 2 other doctors raymond and modem or 2nd in the intervening years they expanded the company to other states moving their headquarters to stanford connecticut and changing the name to the farm produce a private family many of them are doctors many never philanthropists a lot of money billions but they are now i hear typical rich people yachts dating models things like that their intellectual people they care about Science Cancer Research on arts a 3rd brother doctor or 3rd sacker revolutionized pharmaceutical advertising or theyre originated a blitz style marketing of drugs aimed at general practitioners through medical conventions as with well known doctor endorsements direct mailing and a sales force giving out free samples and perks. For the response you know wand and trust theres 963 campaign for the new tranquilizer value touted it as a safe nonaddictive stress reliever women particularly were targeted to cure the every day stress of being a wife and mom valuing became the 1st 1000000000 dollar profit drug leading to an addiction crisis by the mid 1970 s. And 1987 dr arthur sack who died a very rich man his successful Marketing Strategies continue to live on the per do farm. To do began focusing on Pain Management 1972 they patented content. Controlled drug release system produced form a believe that if they could link their 12 hour time release system content to an opioid pain reliever it could be marketed for chronic pain without the sudden rush or heroin high to the brain there is an inherent logic to making large acting opioids because obviously convenience you know if youre doses in a day but youd also have your picks and troughs right so you wouldnt have those sudden potential respiratory depression on your own how to bridge your pain at the time opioids had limited use for short term acute end of life pain neither are markets where fortunes are made you know all of their sales materials for targeted to get to get the drugs out of the oncology suites and into the hands of local practitioners to do began funding organizations that endorsed long term use of opioids for common conditions in 1993 they established partners against pain quote to help alleviate unnecessary suffering by advancing standards of chronic pain care through education 996 saw the launch of the 12 hour extended release synthetic opioid designed to be safe for both acute and long term chronic pain they called their new revolutionary drug oxycontin. The next step was to convince the skeptical medical profession of the safety and effectiveness of their powerful pain reliever her due at the time it launched in 1996 really opened New Territory in terms of aggressive promotion of narcotics they did things that really had never been seen before oxy khat was really one of the 1st pain killers that was marketed to general internists and the public for moderate pain they are the company that sort of an hour. Originated the playbook inspired by the Arthur Sackler playbook producer launched a Marketing Campaign to sell oxycontin through multiple levels of attack. Its number one educate the medical community from 1906 to 2001 produced conducted national Pain Management and speaker training conferences and resource in florida arizona and california there in appropriately influencing maybe even corrupting 5000 doctors Nurse Practitioners and nurses to just sell the koolaid several videos were created named both doctors and patients to encourage the use of opioids as a long term safe methods to treat chronic pain one such video was entitled i got my life back the Video Centers around dr allen spano sent his patients personal Success Stories thanks to oxycontin im back now maybe not can enjoy every day. Since ive been on this new pain medication and i have not missed one day of work these videos were seen by about 15000 doctors through direct marketing seminars and medical school. Is youll be dia a reflection of reality. In a world transformed. What will make you feel safe. High salacious community. Are you going the right way or are you being led. Away. What is faith. In a world corrupted you need to descend. To join us on the death. Or inmate in the shallowest. Be a. Film. We now know that in patients who have no history of Substance Abuse no history of chemical dependency the likelihood that the treatment of paid using it opioid drug which is prescribed by a doctor will need to addiction is extremely low people like Russell Portnoy and many others were teaching that addiction was rare and these false words and that we should be comforting people in chronic pain just like we have learned to convert people with cancer pain and in fact if you dont do that youre probably going to be found wanting these are what is termed in the industry a k o well or a key opinion leader and if a drug company can hire these k o ls they dont have to do the promotion themselves and in fact a lot of what the k o l say to other doctors and other practitioners doesnt have to meet the same level of scrutiny by the f. D. A. Doesnt have to even conform to the labeling instructions for the drug a generation of physicians were trained that opioids were effective for chronic pain and unsafe blitz number 2 promote the drug they increase their sales force and their position call this these sales reps were offered lucrative bonuses their average compensation. Was about 55000. 00 but they could get that increased by an extra 250000. 00 bonus if they could get enough doctors writing prescriptions if you can increase your salary 5 fold youre going to cut corners whos the doctor writing the prescription for is that just the drug mill prescription office those questions just were not asked Health Care Professionals received all kinds of promotional perks. And fishing hats stuffed plush toys musical compact disks and of course the proverbial free lunch pharmaceutical companies were off this all the time to get pens in bugs than. Prescription pads for their products were written and thats why you had to do was sign it you could take him out to lunch you can go to meetings you go to the meetings and theres a reception by those guys knew what they were doing and they must have been good at it or they wouldnt have done it but what happened is they sort of. Grey shape the physician to them to be beholding for the goodies that they provided for them theyre all guidelines for what the sales rep can and cant say that youre not sitting in and not lunch im not saying and on that lunch theres no recording or transcript of it who knows what he said primary care doctors who fell for this began prescribe being aggressively people always say follow the money theres considerable amount of money involved in a prescribing of opiates purdue paid honorarium speaking and teaching fees to doctors boarding the oxycontin bandwagon he was taking about 100000. 00 a year. And then we looked to see how much the drugs that he was writing prescriptions for were costing us and so the drugs he wrote for those Drug Companies cost us 500000. 00 a year so they can easily target dark jurors that are covering 80 percent of all of the narcotic prescriptions and thats what pretty good blitz number 3 get the state and federal regulatory agencies on board as well as the legislative branches big pharma is one of the most powerful lobby groups in washington they have armies of lobbyists that they use to reward congresspeople to reward senators most of it is done legally and above the board and in fact if you look at the websites that are out there you can see how much money is paid by each drug company to each senator and each congressman but theres also a lot of sort of dark money that goes for you know Political Action committees and other organization. Since that that we really dont know about in our system of special interest politics. The special interests unfortunately often are the ones that carry the day when it comes to produce pharma there was essentially an unholy alliance between. The Company Executives and the Advisory Board of the f. D. A. They reviewed the drug big pharma is supposed to be regulated by the f. D. A. But unfortunately through the laws big pharma is actually paying the f. D. A. Very large sums of money to review their drug applications so the f. D. A. Doesnt do independent testing ive never bought into and that has taken account of the Drug Companies Clinical Trials for them i was investigating whether or. Where their Company Executives were essentially writing the advisory decision. That legitimized approving this struck the joint commission that accredits Health Care Organizations mandated pain is treated like the 5th vital signs as patients routinely had their temperature and blood pressures checked doctors were expected to ask each person to rate their pain on a scale from 1. 00 to 10. 00 doctors and hospitals were mohnish to if they did not treat this pain the joint commission developed this pain as the 5th vital sign. As part of a grant to that was provided to them by the Pharmaceutical Company Purdue Pharma the joint commission on accreditation of Healthcare Organizations recently defined and adopted stringent pain standards on the basic thrust of our new standards is that organizations and practitioners have an obligation to ask the patient even if the patient doesnt look like he or she is in pain ask them to be surprised to hear when you go to a Doctors Office how they ask you are you having paid. Though you may go for a raise that has nothing to do with pain which just added lighter fluid to the fire because because it became equivalent to say if you have pain you need opioids. At least in the United States you know 2 plus. You know i mean probably not for making people smile an oxy contemn produced marketing of oxycontin thats depending on how you look at it very successful very tragic all the marketing legislative maneuvering cash and free giveaways handed to doctors and politicians might have been justified if opioids were a safe effective nonaddictive treatment for chronic pain but they werent my personal experience that it wasnt working. That i was watching many of my patients deteriorate. A few deaths. Retrospect clearly related to my prescription produce own sales reps were saying that the rate of addiction is only one percent. With r. C. Con and that was clearly just false when you go back and look at the original data on which the just which their claim that that opioid use or Pain Medicine used for for treating pain doesnt cause addiction is scary the rights of addiction among pain patients who are treated by dont tolls is much less than one percent cited a study by porter and chick few bothered to check out the source of this critical statistic in 197917 years before the creation introduction of oxycontin. Dr herschel jek used boston universitys new crew database to satisfy his curiosity of how many hospitalized patients became addicted to opiates grad student jane porter helped compile the statistics dr Jacques Rogge of our press secretary typed it up and submitted it to the new england journal of medicine. Short letter was one of the many printed in january of 1980 the power graph simply stated the statistics and made no conclusion. What everybody was citing as evidence that we didnt have to worry about getting our patients addicted in some cases this was being described as a landmark study it was this one paragraph a letter to the editor this of course would tell you nothing about the risk of addiction when you put a patient on long term opioids but it turns out in fact they have always been just as addictive as we always knew they were there for many hundreds if not thousands of years when people used the obvious see it in the early derivatives of opium for. Those patients began to exhibit symptoms of tolerance and addiction to do former was quick to pacify fears we were often taught that tolerance imply the diction but it doesnt tolerance just means that you may need to increase the dose of the drug to get the same effect but that doesnt go along with compulsive use of the trial it doesnt go along with any of the other things that with the concept of pseudo addiction what we were told was that if you had a patient coming in early who looked addicted that it wasnt addiction it was a pseudo addiction pseudo addiction is a fairly new term attorney came in about 990 but its crucial pseudo addiction is. When a patient is looking the life of a drug addict because pursuing relief so pseudo addiction is a relief seeking behavior in this state as drug addiction produces remedy for socalled pseudo addiction actually endangered lives if you had a patient who appeared addicted to educational message was that you should increase the dose of the opioid. Give them more opioids and sure enough if you give somebody whos addicted all of the pills that they could possibly want they do stop coming and orally they spend the day and narcotic stupor on the sofa the average daily dose went from about 80 milligrams a day to over 140 milligrams exotic just within a couple of years and its shifted tremendously from the slightly weaker schedule 3 opioids to the stronger longer acting schedule. So by now the horse is out the door is closed youve got people running around thinking believing that they need these opiates to have a peaceful successful life completely pain free will the price that they paid was their dependency an addiction to opiates dr peter Grace Research assistant professor with the university of colorado boulder published a study indicating that opioids like oxycontin when used long term increase chronic pain rather than the long term use that really isnt scientifically justified by now study actually suggest that. The long term effects might not just be the absence of benefit but actually that it might be causing a long time time release opioids when crushed snorted or injected. Rushed to the brain similar if not better than illegal heroin. Young people began diverting the drugs described or stolen from medicine cabinets to get high this to lead to addiction and overdose the children using oxy codeine by children i mean people between the ages of 12 when theyre starting up to 25 all those children they crush the oxy code and they can get a whole day supply out of a sustained release but they became 2 kinds of opioid addicts the abusers and those unknowingly addicted to a drug their trust a doctor had prescribed in the 1009. Linda gee and noddy from exeter New Hampshire sought treatment for back pain and fibromyalgia at her local clinic at one point. 150. 00 milligrams however they do have no patches plus oxycontin vicodin i had a woman that lives in my building said to me you drive like you would cross and that was because of the you know i dont drink so well and you never did anything other than what you. Write i know their practice was the off label use of drugs this is the use of drugs to treat other than what they were designed for off label use is not illegal or regulated by the f. D. A. Doctors began prescribing oxycontin for migraines and depression theres no law against writing the drug for an off label use so there might be the drug detail guy comes in your office and you know with a wink and a nod and says you might want to use drugs for this because some other doctors we know have used it for even though its not approved for that in addition to oxycontin other opioids were put off label use one of which was methadone a drug used to treat heroin addiction. The derivatives became so huge in size over a quadrillion. The size of the actual stuff to the point where the stuff is meaningless derivative matter and so the best derivatives now are increasing so as derivatives on top of derivatives and this is how you get to a place of negative prices on oil because when you trade Oil Derivatives are not trading youre trading purely on the direction of a price based on a derivative thats based on. Other derivative or there is no underlying. Crime Afshin Rattansi were going underground on the anniversary of the publication of the structure of d. N. A. By british scientists watson and crick and from a country estimated to have had the worst coronavirus death rate in the world bar Donald Trumps United States coming up on the show the United Nations special rapporteur on the right to food on the possibility of coronavirus creating a post endemic World Without hunger after centuries of inequality and greed and the bell Ribeiro Addie elected to represent one of britains most deprived constituencies of decembers general
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