Shionogi's Novel Antibiotic, Fetcroja (cefiderocol), Has Been Selected by UK's NICE / NHSE&I as Part of an Antimicrobial Subscription Style Reimbursement Model Enterobacterales and non-fermenting species such as P. aeruginosa, A. baumannii, and S. maltophilia, makes them difficult to treat and results in high mortality rates. 7,8 The World Health Organization have identified carbapenem-resistant strains of Enterobacterales, A. baumannii as the top priority in the research and development of new antibiotics. 9 Cefiderocol is the first antibiotic to address all three major mechanisms of carbapenem-resistance and is an important new treatment option to address this urgent unmet need. 10 Cefiderocol Cefiderocol is the world's first siderophore cephalosporin antibiotic with a novel mechanism of entry through the outer membrane of Gram-negative pathogens by using the bacteria's own iron uptake system to gain cell entry, acting like a Trojan horse.