Structure of SARS-CoV-2 cytoplasmic tail uncovered The current coronavirus disease 2019 (COVID-19) pandemic has claimed over 1.9 million lives so far, and scientists have been racing to develop vaccines that will curtail its spread. Most of these target the spike (S) protein of the virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike is anchored to the host cell membrane, as it mediates viral binding to the host cell receptor. This is the angiotensin-converting enzyme 2 (ACE2). The virus's cytosolic tail also interacts with the host cell to promote its entry into the endoplasmic reticulum (ER). A new study appearing on the