The role and ancestry of the SARS-CoV-2 spike protein glycan

The role and ancestry of the SARS-CoV-2 spike protein glycan shield


The role and ancestry of the SARS-CoV-2 spike protein glycan shield
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is a class I fusion glycoprotein responsible for interacting with the angiotensin-converting enzyme 2 (ACE2) receptor on the surface of human cells, enabling cell entry. It is the primary target of both natural and vaccine-acquired neutralizing antibodies.
The spike protein is coated in a thick glycan shield that plays a role in target site recognition, towards both the ACE2 receptor and neutralizing antibodies, and in conformational stability, modulating the state of the spike protein between closed and open forms and granting stability to the open prefusion form, which affords enhanced affinity towards the ACE2 receptor by presenting the receptor-binding domain.

Related Keywords

, Michael Greenwood , Panela Structure , Glycan , Protein , Sars , Sars Cov 2 , Spike Protein , Ace2 , Angiotensin , Angiotensin Converting Enzyme 2 , Antibodies , Cell , Corona Virus , Coronavirus Disease Covid 19 , Enzyme , Glycans , Glycoprotein , Glycosylation , Receptor , Respiratory , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Syndrome , Vaccine , மைக்கேல் கிரீன்வுட் , ப்ரோடீந் , சர்ச் , ஸ்பைக் ப்ரோடீந் , ஆன்டிபாடிகள் , செல் , கொரோனா வைரஸ் , நொதி , ஏற்பி , சுவாச , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , நோய்க்குறி , தடுப்பூசி ,

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