As cancers grow in the body, changes happen in the dna of the body. What happens is those tumours start shedding fragments of that dna into the bloodstream and what the grail this is bbc news with the latest headlines for viewers in the uk testis the bloodstream and what the grail test is able to do is detect those and around the world. Fragments of dna and they have very a call for a rethink over specific patterns associated with them which mean that we can tell Englands Covid tier system but the government defends placing most of the country under tougher whether or not it is likely to be a restrictions after lockdown ends. Cancer and moreover, if it is, where in the body that signal is coming if people do follow the rules, from so we can actually help the if we do make the tiered system doctors to figure out where to look work, then as i say, there is every reason to believe so they can determine very quickly that they could de escalate and go down a tier in time for christmas. Northern ireland has entered a two whether there is a cancer there and week lockdown from today as stricter move on to treating it. What is the covid 19 restrictions come into force. The British Government asks the uk medicines regulator to assess real liability so far as far as you the oxford vaccine bringing the vaccine one step closer know . Clinicaltrials to a possible rollout real liability so far as far as you know . Clinical trials have real liability so far as far as you know . Clinicaltrials have been real liability so far as far as you know . Clinical trials have been done largely in the United States and these have shown that the test works do get in touch with your thoughts on the different with a very high level of accuracy in terms of being able to predict restrictions in place around
the world and the latest whether someone does have cancer or on Vaccine Development im on twitter its annita mcveigh. Not. And moreover a very low level of what is called false positives, donald trump says he will leave in other words not saying someone the white house if the electoral has a cancer when they do not. Can college formally confirms joe biden as next us president. Certainly i will. You give me some numbers on reliability . The false positive rate and you know that. Is less than 1 . Which is very low but i think that there will be a lot of things happening between now and the 20th of january. For any test, any diagnostic test. A lot of things. Indian farmers protesting against a new law are driven back by tear gas as they attempt to march into new delhi. A bbc investigation has discovered we have had great difficulty that british clinics are offering so called virginity tests which have been condemned by the World Health Organisation previously in oesophageal cancers, and the united nations. Lung, pancreas, it is able to detect those cancers with a sensitivity of argentina bids farewell Something Like 75 at early stages. To Diego Maradona in buenos aires as one of the greatest footballers from going from a position with of all time is laid to rest at a private ceremony outside the capital. Nothing, we should be able to detect and coming up theres the majority at an early stage. What no better time to talk about families after a hugely
challenging year is the risk of false negatives . The duchess of cambridges message as she launches major there are obviously going to be new research on parenting. Some. The Mammography Programme we use for string Breast Cancer only detects about two out of every five Breast Cancer. No such thing as a test which would detect every cancer case. But the sorts of sensitivity hello and welcome if youre numbers we are seeing a very watching in the uk or around the world and stay with us missing. This is why we want to now for the latest news and analysis from here and across the globe. Anger is growing amongst conservative mps here in the uk after the government said that the two highest levels of coronavirus restrictions would be confirm. How many have been trialled imposed on nearly all of england, when the lockdown ends on wednesday. In the us . Over 100,000. 165,000 seven tory mps from kent which will face the most severe measures have written complaining people in england, it will take to the Health Secretary that the blanket restrictions three years to get the results. Will are unfair and risk undermining you have an idea before that of the public support they say theyve
success rate or not . We will monitor secured a meeting with matt hancock. These maps show which areas of england are in which tiers before and after the current lockdown; from next wednesday 32 million how things are going as we progress people will be living under tier 2 restrictions, but we want to do it properly and and 23 million under tier 3. Confirm it is clinically performing in the way we expected to at that level but also want to show the tier 2 Restrictions Means no implementation of this can be socialising indoors, with people outside your household or support bubble. Cost effective for nhs. We will be doing that as part of the pilot. Are but you can meet up to six people outdoors. Restaurants and pubs can open there some cancers it cannot detect . But only if they serve a substantial meal. In tier 3 the most as we have shown from the studies it severe restrictions there is no mixing indoors, meeting outside is only permitted in a public space and restaurants can detect about 50, not every type of cancer. The vast majority it does look like it can pick up at least and pubs can only provide takeaway some of those. Why some and not others . It is really or delivery services. Jonathan blake reports. The end of the National Lockdown may be in sight but there are still hard times ahead. The Prime Minister warned yesterday most parts of england would face tighter restrictions than before when the three tier system returns. I know that this will bring a great about. It performs better in some deal of heartache and frustration, especially for our vital hospitality sector, our pubs, our than others. These happen to be in restaurants, our hotels. Those cancers that are very lethal in so many ways, the soul and because the vast majority of all of our communities, which continue cancer deaths in the uk and is to bear a disproportionate share showing very good performance in those. Obviously it could make a of the burden. Massive difference because Early Detection is so important. It is from next wednesday, really critically important. The vast majority of england will be under the high or very high covid alert level, tiers two and three. In all those places, no household mixing will be allowed indoors. Only cornwall, the isle of wight and the isles of scilly will be placed under looser restrictions in tier i, or medium risk. Less than 2 of the population. Many conservative mps are angry we cannot have tess at the moment about the new system, arguing it is unfair that areas for the vast majority of cancers with relatively low numbers of cases have been lumped together which affect 80 of people in the with places where the virus is more widespread. Uk. What has major work different some have called for a rethink,
and want to see more of the evidence and potentially more successful . Decisions have been based on. There have been really fantastic even tier 2 is going to be immensely advances particularly in two areas damaging for a lot of businesses, in the last two years or so. The and limits peoples freedom first is the whole field of to meet their family and friends. Genomics, which we have heard a tier 3, of course, even worse. Great deal about throughout the media for the last several years. But by forcing so much the second is the ability through of the country into those what is called machine learning. Really tough restrictions, very sophisticated computer especially places where the rates of infection have been falling programmes that can analyse patterns to much lower levels, of change is a ten minute level. It i think the government has given itself a much harderjob. Is those patterns we are really while the rules will be relaxed over detecting anally fragments of dna five days at christmas, across the uk, allowing three that we see in the blood through the households to mix indoors, genomic tests. You initially worked on this in the us, a california there is a warning for anyone hoping for a hug from granny or grandad. Based team. Why are you testing in would i encourage someone to hug england . There are a couple of and kiss their elderly relatives . No, iwould not. Reasons why it is so important to do it here. First as we know we have a its not against the law, and thats the whole point, problem in the uk. We know the you can do it within the rules that are there. But it does not make sense because you could be carrying cancer is a very large cause of the virus and if youve got an elderly relative, that would not death in the uk and is projected to
be the thing youd want to do. Become the biggest cause of death the hope in government is that mass very become the biggest cause of death very soon. Become the biggest cause of death testing will help some areas move very soon. One in two of us will down a tier before too long develop cancer in our lifetimes but but there is little expectation of much change we also know on average we do not until at least the new year. Perform as well as some other jonathan blake, bbc news. Countries. Really important work done by Cancer Research uk has shown our Political Correspondent the reason for that, primary reason, iain watsons at westminster he gave me more details of the growing opposition is on average we tend to detect there to the measures. Light. There is a really great opportunity to work with the nhs to see if we can address this and of course the nhs has a large what i think is interesting is that population system where we can there is a kind of perfect storm really look in detail as to how this brewing against these measures that the government could be bringing in, could be best rolled out, and certainly on the conservative actively the purpose of this pilot. Benches. There was a vote on tuesday and looks like there will be a what would you say to the critics sizeable rebellion, perhaps a that say the nhs should not be symbolic victory for the rebels if they can be seen to wipe out Boris Johnson s 80 seat majority and make investing in such a test before it has been proven in large scale it reliant on the opposition. The Clinical Trials . Firstly, reasons for the rebellion, as you has been proven in large scale clinicaltrials . Firstly, it has suggest, are manifold but i think first of all, there was some shock about the numbers of people put into been tested in large scale trials, tier 3 restrictions next week, published in journals and at major
around 8 million living under those scientific conferences. The nhs is restrictions before National Lockdown in england, 23 million now facing those restrictions as of the not funding this pilot. As a result middle of next week. Whats also worried people, you mentioned of demonstrating this and the cost ideological reasons, but certainly effectiveness of this that the nhs the infringements on personal will begin paying for it. Finally, liberty is worried some mps, steve baker, used to be involved in the if successful, what kind of cut in European Research group, now a cancer deaths could we be seeing . Leading light in the Covid Recovery our modelling suggests we could group, the crg, has talked about the reduce the number of late stage authoritarianism of the government, public measures they are introducing and he is very good at organising diagnoses by nearly half. Which would have the effect of reducing rebellions, got a track record. The cancer deaths in the uk by around other reason i think some people are one fifth. All cancer deaths, that upset, not definitely going to rebel is. That would be a very substantial but thinking about it, they are number, many thousands a year. Best worried about the way the tiered restrictions have been imposed, in of luck with it. Everyone will hope kent, lancashire, lincolnshire, all it goes as well as possible. Thank being lumped together into tier 3 and yet within those counties, the prevalence of the virus is low in some areas, high in others and they said the government should be taking you. Afar said the government should be taking a far more localised approach and a pile of former cabinet ministers who
are making these points including greg clark, damian green, who are Northern Ireland has going to be meeting the health re entered a two week lockdown secretary matt hancock in the coming and non essential shops have closed. Cafes, hairdressers days to present their views. Set and beauticians have also shut against all of this, perhaps just seven days after they were allowed to re open following the last lockdown. Our ireland correspondent chris page unsurprisingly, a little bit earlier this morning, the communities secretary robertjenrick tried to give people some cause for hope and reports from belfast. Said we could be reviewing these measures on december the 16th, it is possible some people who find there will be no more scenes like themselves in tier 3 now might get an early christmas present. There this for a fortnight. It could not have come at a worse time. We will will be a meaningful review on or around the 16th of december, we will happily go through to the end of review the evidence against the five test for every local Authority Area february. But to take away two weeks in the country, listen to the views out of the four pre christmas, it is in local councils, there are directors of Public Health and just a wrecking ball to retail. The theres a directors of Public Health and theresa numberof directors of Public Health and theres a number of places which are quite finely balanced across the new lockdown is due to last until country today which could have been, just two weeks before christmas and or there was a strong case to be in here at Belfast City Centre it feels a tiered system 1 degrees lower than a lot busier than usual during these where theyve ended up at on the last few hours before the shops balanced judgment, they are in the tiered system above so in those shut. I am shopping for my
places, and perhaps others in the country, if people do follow the grandchildren and my own children. Rules, if we do make the tiered the clock is ticking, unfortunately. Syste m rules, if we do make the tiered system work, and as i say, there is we will see what happens after the every reason to believe they could de escalate and go down the tiered next two weeks. The clock is syste m de escalate and go down the tiered system in time for christmas. De escalate and go down the tiered system in time for christmasm looks as though borisjohnson will ticking. Services such as be relying on labour to get these hairdressers have been trying to make the most of the pre lockdown measures through a vote next demand. They have been closed more tuesday. That is pretty significant, than most other businesses this isnt it . It is and it looks that year. I am using savings i would way as things stand. One thing that might defuse or at least limit the size of the conservative rebellion have used for future life from as the government promised to everything to do with my daughter produce an Economic Impact through to my husband. Now it is assessment of the measures ahead of the vote. This has been a key demand used. Ministers say it is painful of many of the potential rebels that but paramount. These are hard asks, wa nt to of many of the potential rebels that want to see notjust health reasons, if you like, but the Economic Impact as we have said before, but what we can achieve over these next two of the restrictions and how people weeks makes it as normal as christmas as we can possibly get to. Who have conditions other than covid it might be cupping in the health the start of december is said to be service as well. The government trying to come and meet them to some difficult but there are positive signs. The rate at which the virus extent, if people dont like what they see, it mightjust harden the has spread his falling. It is now
resolve. Lower than in england and wales. Northern ireland has re entered a two week lockdown donald trump has made comments that and non essential shops have closed. Seem to be the closest hes come so far to conceding defeat cafes, hairdressers in the us president ial and beauticians have also shut just seven days after they were election three weeks ago. Allowed to re open despite repeating his unsubstantiated claim following the last lockdown. That the election was rigged, our ireland correspondent chris page he said he would leave the white house if the Electoral College confirms reports from belfast. President electjoe bidens victory. The college is due to meet seasonal shopping is being suspended in two weeks time. In Northern Ireland. From today, therell be no more mark lobel reports. Scenes like this in towns and cities for a fortnight. Welcome to americas mayor. Thank you, mayor giuliani, the devolved government has told for being here. Most shops to shut because its just this wednesday at this public hearing on the election classified them as nonessential. In pennsylvania, Donald Trumps lawyer Rudy Giuliani revealed his the owner of this jewellery store team were checking graveyards says the closure couldnt have to confirm their unsubstantiated come at a worse time. Claims that thousands of mail in ballots were submitted by dead people. President trump on the phone wed happily close from the 24th through to the end of february. Was sounding jubilant. We wouldnt bat an eyelid on it. But to take away two weeks out of the four pre christmas, its just a wrecking ball to retail. This was an election the new lockdown is due that we won easily.