The top of the pack. He has tumbled to 10th place and in national polling, he was down below 1 in the most recent cnn orc pulpit i want to go to poll. I want to go to Mark Halperin. Explain to us why scott walker ended up where he did today, on the way out . Mark you will hear a lot of consensus from republicans and pundits about what happened. Scott walker never produced a major League Operation or candidacy. His own performance was at the center of that. He had numerous things were he said things on the stump work questions were raised about his competence, his readiness for the major leagues. No Major League Fundraising operation, no major League Performance in the debate, not a majorleague staff. He was accused as a long time political operative himself of micromanaging. In a competitive field, scott saw a precipitous decline and the thought of going out without money in the till without an improvement i performance is too much for him. John he was a guy who won election in wisconsin three times in four years. Election andll reelection in the face of a huge amount of spending from organized labor to take him down. That made him a national figure. Two a lot of conservatives, his fight against unions made him a hero. He took that with him into this race. It gave him a standing as a winner and a fighter and he looked like someone who could do what would be ideal cycle, who would appeal to the establishment wing of the party and an at the establishment wing. He is an evangelical christian and a fighter. Gov. Walker we want to extend our sympathy to the family of Wisconsin Supreme CourtJustice Patrick crooks. We will let the Supreme Court make the official announcements, but we want to pass on her prayers and sympathy to him and his family, certainly his wife and children and extended family. More coming on that in the days to come. As a kid, i was drawn to Ronald Reagan because he was a republican and a conservative. Most of all, i admire him because of his eternal optimism in the american people. That thought came into my head when we were all standing on the stage at the lake reagan at the Reagan Library last week. Ronald reagan was good for america because he was an optimist. Sadly, the debate taking place in the party today is not focused on that optimistic view of america. Instead it has drifted into personal attacks. In the end, i believe that the voters want to be for something and not against someone. That is talking about how bad things are, we want to hear how we can make them better for everyone. We need to get back to the basics of our party. You are a party that believes people create jobs, not the government. Economy way to grow the is to get government out of the way and build it from the ground up. We are a party that believes the success in government is having people not depending on the government. A are the party that believes Strong Military leads to peace through strength and that will protect our future generations, and that good will triumph over evil. We are the party that believes in the american people, not the federal government. These ideas will help us win the election next fall and more importantly, these ideas will make our country great again. Ofrefocus on the debate these types of issues will require leadership. I was sitting in church yesterday. The pastors words reminded me that the bible is full of stories about people who were called to be leaders in unusual ways. Today, i believe that i am being called to lead by helping to clear the field in this race so that a positive conservative message can rise to the top of the field. Spendhis in mind, i will my cap suspend my campaign immediately. Republican other residential candidate to do the same so the voters can focus on a limited number of candidates who can offer a positive conservative alternative to the current frontrunner. This is fundamentally important to the future of the party and more importantly, to the future of our country. This is a difficult decision, as so many wonderful people stepped up to her came. We are very thankful for the outstanding volunteers and the excellent staff who helped us throughout the campaign. You all have been like family to us. Speaking of family, i want to personally thank my wife, rock, aswho has been a well as our two amazing sons, matt and alex. I want to thank all of our family and friends for love and support. Most of all, i want to thank god for his abundant grace. When or lose, it has always been more than enough. Thank you. Scottthat was Governor Walker of wisconsin making a brief, pointed, and somewhat unusual speech in madison, wisconsin, announcing that he is essentially ending his campaign. I want to bring back my friend Mark Halperin. I dont think i have ever releasing a withdrawal speech go like that. I have seen a lot of them. Scott walker called on republicans to drop out of the a consensusl on rallying against donald trump is what extraordinary. Mark more and more resources, not just the candidates who drop out and theres staffers, but more and more resources will be devoted to stopping donald trump in the wake of what has happened. In the establishment, not a lot of sympathy on a professional level for scott walker. They did not see him running a strong campaign. The message is that there needs to be now, not in march, some effort to find strong establishment candidates with the political skills to take on donald trump. Gave a prominent voice to that sentiment. John yes. Quite unusual to use a withdrawal speech essentially as a rallying cry. Scott walker was saying there that he was going to take one for the team, which is to say the Republican Party. He said he was leading by leaving the race and calling for everyone to rally around someone else. You that agree with there are a lot of energies starting to build in that direction in the Republican Party and the establishment wing of the republican aarti, but where do you think that Republican Party, but where do whoseink that will go and benefit would accrue and in the short term . Mark the two guys out,. Walker, did not get out because they graciously want to get er, did perry and walk not get out because they graciously wanted to defeat trump. They got out because there was no money. Rubio, johnrco kasich will move aggressively to try to get some of walkers Financial Support on the grassroots side. For donald trump and ted cruz to move aggressively and probably with the most success to sign up walker supporters. There are a lot of grassroots people who were for walker that need a home to go to. His poll standings suggest she did not have broad public support, but now there is a fire sale for walkers of others and i think 5, 6, 7, 8 people could say tonight with walker out of the race, there is room for me here. Given how low he dropped in the polls, there is no reason to say that they will get walker supporters and move closer to trump, carson, or fiorina. Calling, go to our John Mccormick. Covered the scott walker beach. You wrote about him this weekend and what seemed to be a lastditch effort to go for broke in the hawkeye state, where you now are. Tell us whether you had seen any signs of this coming or whether this did come as much of a surprise as it did the rest of us. John m. you could tell there was something off. I did not have a sense for that. The cnn poll had shown him below 1 or whether he was thinking about what he did today. He put on a brave face. He said he was going to spent 10 days a month and i will going forward. Hisas going to become Campaign Headquarters and people would field use running for governor there. That changed overnight. His wife, tonette, was pulled aside by a supporter at one of the events late in the afternoon. I did not hear the question that was asked, but she said he is going to continue to be governor of wisconsin third 2018, the matter what happens. Lookingd tell they were beyond the campaign a little bit. In terms of what he said about finding an antitrump, keep in mind that scott walker is very previous, a fellow and i would be interesting to see if those two gentlemen had a conversation this afternoon. John h. he made it sound like a personal decision, that he was doing this for the wood of the party, leading by leaving the race. Good of the party, leading by leaving the race. His money was drying up rather rapid rate. He was having fundraising trouble before the debate at the Reagan Library in simi valley last week. After that debate, things got more dire with an hours of that debate. What is the degree of panic and the degree of pessimism among walkers donor class, people who supported him financially and others who were establishment and nonestablishment supporters of his, over how bad things had gotten and how quickly they got that way . John m. there was huge nervousness. There was a Conference Call scheduled immediately after the debate were walker got on the line along with his Campaign Manager and they tried to calm and donor nerves. They put forward their new plan, that they would focus on iowa almost exclusively. No, i interviewed some donors over the weekend and they said they were staying loyal to them, they were maybe starting to look at other candidates, but in his core group of people, there is some real, true believers that very much sort of likeds union record in wisconsin and found it to be a rallying point. There was nervousness, but there were many people committed to him and will be looking for other candidates to support. John h. John Mccormick, thank you, calling in from des moines, iowa. Going back to you, mark. There was a lot of discussion at the debate and in last weeks talkingibrary debate, about changing leadership in the campaign, about requiring, chief strategistCampaign Manager for walker being forced out, donors demanding change. This afternoon, word was spreading that walker was about to drop out. One of his biggest donors in new york said this was great news because rick wiley was quitting. Bundler blur this was surprised to hear walk was stepping down. Why not do a full leadership reboot and start from scratch . Mark there was not enough time. They were having difficulty convincing walker to make the change and recruiting someone who could replace wiley or be a team with wiley. The financial imperative drove this. Scott walker had a lot of problems. What drove him to make this decision was no Financial Resources to go forward, to pay the bills, and to build something because he would have to fight his way back. I cant emphasize enough the corrosive effect at occurred as some of the people in the Campaign Began to lose faith in their own candidates. Walker made so many mistakes on the campaign trail where he would Say Something wrong, off key, he would get that covered for it in the mistakes would be cleaned up by the staff instead of walker himself, and that did not sit well with people. He performed well in the political fights in wisconsin, but was not dealing with the major leagues. Yet candidates like donald trump, carly fiorina, jeb bush, are playing at the National Level in the media against other republican in a way that is robust. Walker had not been able to replicate that performance. John while there was no moment that was akin to rick perrys oops moment in 2012, there was moments that indicated his amateurism. One day he seemed to be for ending birthright citizenship, the next day he walked it act, and then settled in a place where he had no opinion on the matter. The markings of a politician who, while skilled enough to triumph three times in four years in a state like wisconsin, was not able to play at the. Ppropriate level mark another factor is he got in the race late. In part because he was dealing with a budget situation in wisconsin. Any incumbent governor running who has columns at home he has low Approval Rating at home here in he was at at home. He was at war with not only did democrats, but the republicans. To continue to do his danger, and the two for performances his day job, and the two poor performances. Plummeting in the national and i will pull and being told after a poor performance in the first debate, zero margin of error, and he he did not step up throughout the three hours. John you need a second act if you are going to make one of these things work over the long haul. He gave some great speeches at the outset for he was declared a candidate that make people look at him as a serious potential republican nominee. He had the calling cards of his unionbashing credentials in wisconsin. When it came time to move to a new phase, he was not capable of doing that on the debate stage or with his feelings on the National Dress were on the stump. Press, or on the stump. When you fall down repeatedly, you often find yourself unable to get back up. I want to thank John Mccormick and Mark Halperin for talking with me. This has been a Bloomberg Politics special report. You can find out more about this president ial race at Bloomberg Politics. Com. Our normal programming will resume right now. Charlie because . Because we havent got the knowledge yet to be sure of the concepts. We have to take this very slowly and very carefully and be aware of the risks. Charlie who makes sure we do this . Selfimposed . Evelyn i think we have a pretty good record for regulating our own act timid tv our own activity. Usphen new technologies let do tremendous things. These tools are not perfect, so they need to be very carefully managed. Charlie thank you and congratulations. Stephen thank you. Charlie back in a moment. Stay with us. Charlie joining me now is james allison. He created a lifesaving Cancer Treatment that harnesses the immune system. Congratulations on the lasker award. Thank you for being here. James thank you very much. Charlie tell me what communal therapy is. James using the bought immun otherapy is. James it is using t cells to go after cancer. Charlie what are t cells . James they are warriors of the immune system. Cells infected by viruses and kill them. Things that are not both to be there, they recognize it as being strange. Charlie what threeontwo this . What drew you to this . James when i was in college, t cells had just been discovered and no one knew how they work. To me, it was fascinating that you could have these cells that travel through your body and look for things that might hurt you. Charlie and attacked them. James even though they are things they have never seen before. Charlie my first question, which amended to start with, is what 32 medical research . James what drew you to medical research . James country doctor. Made house calls back in the day. I really supported it. I thought about being a doctor for a while, but i realized from watching my dad that doctors have to be right all the time. They have to be able to diagnose and treat properly. I figured out early on if you are a scientist, you only have to be right side of the time. Charlie and your business is trial and error. James exactly. Hypothesis, you test it, if you are wrong, you move on. Charlie [laughter] , i hear this term with lots of answers. Lots of cancers. They are talking about with attacks on brain cancer, in terms of using the poliovirus. If this the coming field in cancer . Yes, it is. Ld say the immune system can attack all cancers. Develop, that i helped they unleash the immune system. They dont treat the cancer, they treat the immune system and unleash it. Conceivably, a could work against all kinds of cancer. Charlie remind me why this class of people and im having a conference letter with a group of discerning scientists. When you mention cancer research, your name is at the top of the list for good reason. Explain how you came to discover what you did. Understanding t cells what turns them on and how they are regulated charlie regulated area charlie its a nonscientific question. The idea of cells being turned on and turned off. That is a remarkable idea, that some cells can be turned on or turn off. James with the immune system, you have to turn them on. You probably have 100 million t cells with different receptors. They can recognize different things. When there is a cancer, they have to multiply very, very fast. You go from a few dozen to tens of millions in three or four days, but you have to stop that. T is why you others found a few others found that there is an ignition switch, and another , it is like the gas pedal. We found another molecule that actually stops in the response immune response. Charlie so you got a starter and an ender. James exactly the the idea we is if tumors get big before couldcell starts, you eliminate them. Charlie assume that immunotherapy has the potential you think it does. Are we looking at the end of cancer . James i would like to think that, except we have a long way to go. 22 of patients that get a single round of treatment with the drugs we developed are alive for 10 years and they are basically cured, if you look at that way. 22 . We have to get that higher. Combination with the same class, where about half the patients respond. We dont know how long it is going to last. Our challenge now is to make this work in other types of cancer. Charlie which cancers might that be . James the ones where these drugs are approved our lung cancer and melanoma. When you get down to Prostate Cancer and Kidney Cancer and brain cancer, they are harder because they do not produce as many antigens as lung cancer in all those. Charlie what else is going on in the world of cancer . James there is what used to be called personalized medicine, and now it is called Precision Medicine where you do genomic sequencing and identify the cause of cancer. It is normally something that would tell itself to divide only unde