Rather restricted area north of miami. That is a result of the fact that we have travellated cases that were infected elsewhere, came to the continent, move back home, wherever, got bit by a mosquito, then transmitted it to someone. When that happens, you have to get Mosquito Control and do it aggressively. You also have to make sure you protect pregnant women and make sure that in that area, pregnant women protect themselves as best as they can. Stay indoors with airconditioning, make sure the screens on their doors and windows are intact. When they have to go out, put long close on that project most of their body, and then put insect repellent on. The people who are pregnant who are not in that area as you all know now, the cdc and the state of florida has put a restriction guidance to have pregnant women not go to that area right now. Also, since this is transmitted sexually, youve got to be careful that if you are exposed, you have to go by the cdc guidelines for sexual transmission. We have a situation in florida, and i would not be surprised if we see additional cases in florida or other states along the gulf coast. Again, the answer right now, in the absence of a vaccine, is Mosquito Control as well as protecting people from getting bit by mosquitoes. Charlie a bit of history for us and for the audience, it came too far, to miami, how . There were people who were infected outside the continental United States, either in south america, central america, the caribbean, particularly puerto rico. They come from the United States, or people who are in the United States and visited those places and then came back. In florida, there are 1600 travel related zika cases in the United States, and florida, there are almost 400. And since we had copious mosquitoes in florida and all across the southeastern part of the United States that are capable of transmitting zika, somehow, somewhere, a mosquito bit that person that was a travel related case, then it someone who had never left the continental United States and has no travel history, and who has not had any other contact with a zikainfected individual. What we are seeing right now in florida is a cluster of cases in a rather restricted area. Clearly this happens by a bite of a mosquito who originally bit someone who got infected someplace else, and now we have a chain of transmission here in the United States, particularly in florida. Some cases are individual, and some are linked. Charlie is the war against mosquitoes a winnable war . If you are thinking of eradicating mosquitoes, we will never win. We could suppress them enough to break any chain of transmission, to make it very inefficient to be transmission. When you have copious mosquitoes all over the place, you make it much more likely that you will hit one of those infected people who will then infect someone else. When you get the mosquito density very far down, you dont have to get rid of every last mosquito, but youve got to get the density down enough to get rid of and block that chain of transmission. Charlie why are more main infected than women in the miami case . You can never tell. I think the number 15 is so small that you cant do a Statistical Analysis on that. Whenever you see situations outside of the florida situation, but with other diseases where you see more men infected than women, its usually because in certain societies men get out more than women. Thats in general. That in societies like america, where women are out working and doing things as much as men, i dont think that really holds. Charlie what happens if you are infected with the virus . If you are not a pregnant woman, it is generally very mild. 80 do not get any symptoms at all and are unaware they have been been infected. 20 get bitten and they are usually relatively mild, rashes, joint ache and pain. That usually lasts about a week. The virus generally disappears in seven days. There is a rare, rare case of a neurological syndrome that some people get in a very rare instance, associated with different viruses including zika. It is the pregnant womans vulnerability that sets this apart as a very special kind of infection. Charlie and what happens to pregnant women that are infected . When pregnant women get infected during their pregnancy, there is a chance, particularly if they get infected during the first trimester, that they will have a baby that has a congenital abnormality, particularly microcephaly, which is the small size of the head due to the interference of the developmental process of the brain, which generally, when it develops, pushes up the skull in a nice, smooth form. But when the development of the brain is either hindered or destroyed, it does not develop fully and the head looks like it is much smaller. Also, if you get infected later, even though the brain seemed to develop well, it can cave in. It is a tragic situation because it wreaks terrible destruction on the child. Charlie there is also the question of zika at the olympics. Help us understand how severe that is, and the decision by a significant number of people not to go to rio. Ok, when you say not to go to rio, just to reemphasize, if you are a pregnant woman, you should not go to rio, because brazil and rio is still an area where there is active transmission, and the cdc guidelines recommend you dont go. Other people aside, nonpregnant women, lets say an athlete, if you look at the rate of infection now, in august, compared to what it was in january and february, it is now low compared to that. It is not absent, but it really is very low. The reason for that is twofold. Many of the People Living there have been infected already, so they are already in the end dampens the transmissibility probability. The other thing is that the mosquito density is significantly less now because august is their winter, while january is their summer. Even though there is a possibility that you might get infected if you go to brazil, that likelihood is much, much lower than it is in january. That is the reason why we were saying in general, apart from pregnant women, that the risk of going down there and having a serious problem is very low because outside of pregnant women, zika is a relatively mild disease. Charlie and now vaccine trials are about to begin, or have recently began. What are the hopes for the vaccine . We began a stage one trial on august the second, and the phase one trial is continuing now. It will be 80 individuals. The question you asked, is it safe . Mainly, do we have any immediate red flags come up . And doesnt reduce the kind of response that you would predict would be protected . And that looks good, we will know that by the end of 2016, and we will hopefully proceed in the early part of 2017 into a large trial, ranging from 2400 people to 5000 people, to ask the question, does it work . The goal, as the direct answer to your question, is to get a vaccine that will prevent infection, particularly of young women and girls of childbearing age, to protect them from when they become pregnant. Charlie do you assume these trials will be successful . You never assume that a vaccine trial is going to be successful, which is the reason why there are more than one candidates. A Company Started their trial a few days before us. We are going to start another trial in october and another later wrong. Whenever we do vaccines, particularly for something as serious as this, you have to have multiple irons in the fire because you never have a guarantee that any single candidate is going to work, so you put a lot of been in play. Charlie and vaccines are the best hope . No doubt. The best ways that you can address this, get rid of the mosquitoes, which is difficult. As we know in brazil and what we are seeing in florida. Or, get a successful and safe vaccine to protect the population, particularly vulnerable ones such as women who are pregnant. Charlie thank you so much. Good to be with you, charlie. Charlie we will be right back. Charlie we continue with our look at the zika virus and its impact in florida with a conversation with the chief medical correspondent for cbs news, a practicing physician. This is from a conversation recorded on thursday afternoon. I think the number one thing that is going on right now is that every one of my colleagues at every level of government, especially in the health profession, are beside themselves over the lack of funding to help this zika outbreak. Back in february, president obama requested 1. 9 billion dollars in emergency funding at the request of the cdc, dr. Todd freeman at the head of that. Charlie moving money around . They wanted new emergency money. What happened was, nothing. No new funding has been allocated. Almost 600 Million Dollars has moved around. It was money that was supposed to go to ebola and other things. That has to be replenished. What has happened is a love of politics, and where we stand right now, which is a 1. 1 billion compromise bill right now, the holdup is in the senate. Democrats and republicans are pointing fingers at each other, because the republicans put on a writer that the funds cannot be used for planned parenthood support, and there was an issue about offsetting. Democrats wanted it to be entirely about emergency funding. There is a compromise. The bottom line, congress is away on recess, no new funding. I just spoke with the head of the cdc, and he is beside himself. Tom said to me, this is no way to run an epidemic. Charlie we continue this evening with a look back at the ongoing president ial campaign. Republican nominee donald trump has had a tough week. He drew widespread criticism after engaging in a feud with the khan family, the father of a Muslim American soldier and his wife. On tuesday, trump also refused to endorse paul ryan and john mccain in their primary bids. In a fox news poll, Hillary Clinton currently has a 10 point advantage over donald trump. Joining me is mark halperin, the cohost of with all due respect. It is thursday afternoon, where is the Trump Campaign . Mark it is in a bad place. National and state polls are not just the reality of what a hard period he has had, but they have a corrosive effect on the morale of republicans. We have seen, everyone in our business, calls and emails from people in the republican establishment saying, i cant believe this is happening. The quality and quantity of those in the last 48 hours has been extraordinary. Republicans are worried now that perhaps the plan of sticking to trump no matter what is not the right thing to do. Not trying to force him from being the nominee, but abandoning him. Trump has to ride the ship, or he will face a very precarious situation where republican donors, operatives, and establishment types focus solely on the house and senate. Charlie to ride the ship, he has to recognize there is a problem. Does he recognize there is a problem . Mark my understanding is he does. People in the upper levels of the campaign believes that he gets it. He has made Public Comments with television stations that he gets it. He needs to focus on the economy. He is giving a speech on the economy on monday. And on Hillary Clinton. We all know he is not going to be a disciplined candidate in a way any other candidate will be at this level. Charlie will he be more disciplined . Mark i think so. Im not sure it will be enough. Charlie are you sinking it will take more to get people to begin disendorsing him . Mark they will do it in a selfinterested way. I think there will be few people on the ballot in november who, out of some sense of morality, say they cant be for donald trump. First of all, there are 10 states left in the primaries. Even in a general election, 70 of the base of the Republican Party wants him to win. But thats a back of the envelope thing. Think about the house districts that are gerrymandered. These are dominating republican districts. If you are a house candidate, 70 of your base voters are for trump. He is the republican nominee. There is no playbook which says, go into a general election with 70 of your base voters angry at you. It just does not compute. They could stay home, they could vote for someone else. Charlie if donald trump turns it around, in terms of not digging a deeper hole, and against a talk about change and the economy, does not get distracted by personal accusations, if he does that, what makes you think he can win this election . Mark still tough. It will be tough for any republican because of the electoral college. He does not need to improve and that many states. He had a good fundraising month. Some of us thought he would have the potential to raise those small dollar donations. They can keep giving him money. If he runs good tv ads and focuses on those handful of states, if he makes the election less about donald trump, more about Hillary Clinton, he could be in the game. Charlie Paul Manafort says the people who defected they are mostly not surprised about. These were not people that they thought would go to the end for them. Mark i think thats fair. Maybe there are a few exceptions where the they were surprised. Trump is an antiestablishment candidate. He has views about Foreign Policy that are outside the mainstream of the establishment. I thinhe will make it to the first debate. If he has a good first debate, i think he can keep things together. Charlie and no matter how many people conclude that the president suggested that he is not fit to be president , that has not yet stuck. Mark an elite circles, it has. I dont think he would do particularly well at manhattan or malibu dinner parties, but in the Republican Party, as i said, there is a reason that paul ryan said, my nominee said something that was racist, but i am still for him. It is still in their interest to try to hold things together, because the minute that people like paul ryan abandon him, there would be chaos in the base of the Republican Party, and they run the risk of losing the house of representatives. Charlie thank you, mark. Back in a moment. Stay with us. Charlie javier munoz is here. Last month, he replaced Linmanuel Miranda as Alexander Hamilton in the awardwinning musical hamilton. He was previously the alternative in the role, dating back to january 20 15. He also serves as mirandas alternative and later replacement in the 2008 Broadway Musical in the heights. I am thrilled to have you here. Congratulations. Javier thank you so much. Charlie you and linmanuel go back how long . Javier we met at 2005 for an audition for what was a Development Workshop for in the heights. They were auditioning for a role that no longer exists in the show. I went in and saying a George Michael song for him, the dream team. The rest is history. We just became best friends. Shortly after that is when we went a different route. We were at a theater complex in connecticut, and there was an idea to audition me. When i got cast for those two weeks to do that for lin is when we forged that friendship. It is unlike any working relationship i have anywhere. Charlie in the sense that it is intimate, inspiring, constructive, collaborative, everything . Javier yeah, and it is a friendship too. It takes great trust to do what we do in the room together. For two actors to put aside ego and Everything Else and just make the work the focus and build a character together is very unique. Charlie this is a simple question, but everybody thinks about it. What is his genius . Javier i think in my work with him, i find it to be it is what he is listening to. It is his perception of the context of whatever he is in, whether it is immersing himself in music, or tv, or a book, or a conversation. He hears. I mean he takes in information and perceives at a level i have never experienced in anyone else. It is getting to the heart of each thing. That, i think, is what he puts into his writing and work. Charlie but if you had to list and define all these skills, is there one that stands out more than others because it is so close to perfection . Is it the music, the lyrics . Javier i think it is his humanity, i really do. And i think that is what allows him to get to the heart of every interaction and engagement he finds himself in, and it comes out in his writing, very much so. Charlie i would think writing, too. Writing is how he defines Everything Else. Javier absolutely. Charlie Alexander Hamilton. How are you different than he is, other than the fact you are a different actor . Javier i think the distinction i bring to hamilton is rooted in the life i have lived. It is challenges, obstacles, mountains i have climbed that are unique to what my journey has been as an individual, as a human being on this planet. I put myself through college, various health challenges, and just coming to terms with a peace in my own skin as a human being. All those things i pour into Alexander Hamilton. The fight i have in my life is the same fight she has. Charlie but these are not ordinary health challenges. You have had to have within you a real strength. Javier that is rooted within my family. My team, my support are my brothers and parents. No matter what is going on, and in the past, no matter what has been going on throughout my life, the safest place i could be was home. Charlie because they gave you not only comfort, but also courage and strength and javier yes. Charlie this is a terrible thing, to battle hiv. Javier it was a difficult thing. Charlie difficult defines challenge much better than any other word. Javier it was 2002 when i was diagnosed, and i would like to think that much of the stigma and weight of being diagnosed with hiv has been lifted, and there is far more work that we have to do, and on a global scale there is even more work to be done. In 2002, i needed a lot of love and support, and my family was there. Charlie not to give up, not to javier absolutely. And to just be there through i think anyone prior to the current medications that are available, which are remarkable, those ea