Alzheimers disease. Call your attention to one stock. Those would be the shares of biojin right now up 7 . Up 30 in the past three months at alltime highs now after releasing very encouraging data on an experimental alzheimers drug. Telling us about it at this time yesterday and shes now back with more detail. Hi, meg. Hi tyler. Incredibly High Expectations for this drug leading into today and analysts say biogin met and exceeded them. Shocking investors saying the medicine appeared to slow the cognitive declines associated with alzheimers and today how well the drug appeared to work both on memory loss and clearing of the am lloydoidloyd plaqued that build up in the brain. Next step, find balance between safety and efficacy. Results of early. Doctors are encouraged and important to note the drug was tested in patients at very early stages of alzheimers disease who might benefit if it reach ares the market. Next the Company Moves the drug quickly into a phase three study jumping over the middle stages of trials. If all goes well analysts say the medicine could reach the market in 2018 or 2019. Now thats a lot of excitement about biogin stocks. Several analysts raised price targets, going as high as 532 because a successful alzheimers drug could be huge estimated up to 10 billion in annual revenue. 5 million are expected to have alzheimers a number that can triple. So many of us touched by it. Thanks, meg. Biotechs on fire. Check it out. Up 45 in just 2. 5 months. This year up 90 , thereabouts, over the past one year. What is driving the biotech boom . Where does all of this excitement come from and how much farther might they rise . Dominic chu with details. That pro shares ultra bio tech as leveled play mp pla fips the return. The booming biotech business a lot of other stocks there doing all right just on their own. Some of them large cap, some more small and medium cap. Look at names. Check out the ishires nasdaq biotech particularly ibb up about 42 , this over the past 12 months. This tracks a lot of those large and midcap maybe some small cap Bio Tech Companies up huge over the past year. Look at some of the large cap winners really driving the performance in the s p 500, these are some of the names were talking about. First look at regenreon. Year to date up 18 . Big name in terms of eye disease. Treat. Big drug celgene cancer product. Vertex and gilead high profile hepatitis c treatment, is a valued y savaldi. Big names in performers. Hot sector. Dom, thank you. Brian sullivan counting russian. One two three here you go. According to baker hughes tyler, down 41 rigs from last week. Interesting for a couple of reasons. One, its a lowest number of drilling rigs out there. Only talking oil now. Lost 15 gas. That is the lowest number of oil rigs since march of 2011. What is also interesting is we were down 56 drills rigs from last week. So while we declined another 41 in oil, the rate of deck clination, rigs pulled off slowed down the first time in a while. 41 lost last week. 56 the previous week. Price of crude oil looking here up a nickel. Not seeing much of a reaction there, guys. Canada crushed again, but a lot of weather stuff going on in canada. Its cold people arent moving rig, whatever. Lost 80 rigs last week. Canada has lost almost half its drilling rigsdown 41 in the United States. Lowest since march 11. Again, guys mandy, the rate of deck clination of the rigs coming down slowed. You were saying wti up 5. 4 now. Look at the sectors on the s p, energy, biggest winner. Back to biotech talking about it a moment ago. Justified or not, biotech is fueling the nasdaq high today. In fact the index blowing past the 5000 mark hitting a new 15year high. Nasdaq currently 5039. Bertha coombs, the big movers youre watching there . Interesting. We are about ten points way from the alltime high close and a new record on that front. This week its really been the big caps that have outperformed on a percentage basis. A lot of that driven by the bio tech names. The biotech index, the ibb, etf up 6 for the week. Seen a little profittaking this morning but seen a number of alltime highs not just in biotechs but across a number of sectors. Facebook is closing out the week at an alltime high. Starbucks after a lot of news despite the pushback on its social Media Campaign also anthem and a lot of other health care names here that are outside of bio techs. Seeing those big moves but really its been those small and midcap names. Those are at alltime highs. Just, again, starting to see more momentum perhaps some because of the dollar influence and chips today are joining the club. Still well off their yaum time highs. None the less pretty big movers today. Back to you. Thank you, bertha coombs. Talking of joining the club look at the dow. Triple digit rally up more than 2 . Well, 2 this week an on pace for the second best of the year. Dow up by 1. 2 intraday. The trading action. Mary thompson joining us from the nyc floor. Quite a seesaw action this week but overall the trend up . It has. Triple ditch et decline yesterday, triple digit gain today. A quadruple witching friday. Broad based gains here on the new york stock exchange. 26 million shares usually see those levels at 2 00 eastern time. Were ahead of schedule. Quickly check the s p 500 because in addition with the heavy volume with the quad witch another factor it played the technicals broken. Nearterm technical level 2109 to 2111. Reason being, the last you saw. Broke through and now helps to extend the rally today. We mentioned earlier, biogen a leader within the s p 500. One of the reasons its up almost or over 1 now along with a number of oil stocks. Of course, benefiting from the gains were seeing in oil prices and darden restaurants, which came out with strong Earnings Report, thanks in part to strength in its long horse steak house chain. Nike, a winner earnings ahead of expectations warning the stronger dollar impacts its revenue and earnings Going Forward, but investors are shrugging off that forecast. Home depot and chevron another oil stock benefits gains in oil prices today. Dows up 211. Wild swings in the market. Dow higher by 200 points now. Yeah, up and down whatever. How do you play this market, and have the risks risen . Katie nixon with us chief Investment Officer at Northern TrustWealth Management. And also Steve Friedman head of cross asset strategy at ubs Wealth Management lee search. Welcome to you both. Katie, start with you. Have the risks of owning u. S. Equitying markedly increased . Volatility increased, tyler. All im asking about. Real risk. Volatility is risk. Right . Risk around your expected outcome has increased as the outcome has become a bit less certain. What do i do if risk has increased . How do i reposition if at all . So what were telling our clients is, this is a time to just put your seat belt on and try to live through this volatility and sort of peer through the mist to recognize that fundamentals remain strong here in the u. S. And we think the feds going to remain accom in ative. Do they remain as strong as maybe a couple weeks ago in light of the fact that weve gotten a lot of Economic Data that are a little squishy . Right. We certainly have seen Economic Data and a dollar thats rising generally. Think about the Economic Data, we think that gives the fed the ability to be much more patient if youll pardon the phrase, than most investors thought a week ago. So the weak overall macro allows the fed to be were buying companies, not gdp. Buying growing concerns assets a lot of value. A more accommodative fed helps stock. Steve, pose the same question i just asked katie to you. Have the risks of honors u. S. Equities risen markedly . Other than the fact that the market is more expensive than it was a year ago, i dont really see that the risks have risen materially just because were still in a situation where a recession is pretty far away. We dont have easying built in the Company Neither in credit or capital expenditure. I dont see a risk from that signed of things. At the same time the fed basically is ensuring we remain in the sweet spot for equities where there is enough growth out there to deliver Solid Earnings growth, a positive for the market. At the same time withdrawal of Monetary Policy stimulus will be gradual. If i were comfortable, steve, with a portfolio 60 equities right now, and lets say, oh ten Percentage Points of that was overseas stocks would you change that mix in any way . Would you be reducing the u. S. Portion and increasing the overseas portion . Thats actually what weve recommended since the beginning of the year. The u. S. Has been our favorite equity market for a number of years, and this year weve been really growing more comfortable owning eurozone stocks. That now is our preferred region and really just acknowledging that eurozone is in a different phase of the cycle. Much more potential for earnings once they grow due for instance to the weaker euro for earnings to grow faster than in the u. S. Its become a much more attractive to look into the eurozone. Katie, you . If my typical mix was 60 stocks, 40 firsted income would you be changing it in any way now and if i had, lets say, ten Percentage Points in foreign shares would you be upping that or leaving it static . Wed have a little more than that in european equities, tyler. One thing, thinking about increasing that, actually. One of the things that holds us back is the fact that the fundamentals on the earnings side havent improved. Actually seen earnings estimates in europe . In europe. Flail around and fall in some sectors. Until we see improvement looking at a Market Selling above historical average from a valuation, were going to hold back. I infer in what you say europes rise a monetarily driven . We saw it in this country. Financial assets move first and weve seen it in england. Enjoy the snow. Gotten tired of seeing brown earth and grass. Getting boring. Steve, thank you as well. Bow to power lunch. Cnbc. Com to see what they think are the greatest risks to the market. Trying to enjoy the snow. All weve got. Despite today is the first day of spring. Mother nature giving a trick, bringing in the snow rather than flowers, least here in the east. This is the weather channels dr. Greg postel with more. Snow continues across parts of the northeast. Philly, new york hartford likely snowing. Should all end from southwest to northeast across the region late this afternoon and the evening. My guess by about 7 00 8 00 in new york should be done and in southern new england, going to take longer because the system heads out to sea by i11 00 tonight, all over. Central parts of new jersey on into parts of long island and central connecticut. With temperatures slightly above freezing, good news. And im not sure whether thats good news or slushy news but dom chu a market flash . I do. Watching shares of whats happening with one of chinas leading internet tv companies. The shares hitting 52week lows today. The companys Earnings Report yesterday showed losses continued to deepen rising to 143 million. A loss of 94 million in 2013. Revenue last year grew by 33 . A flip side of that story. Youku listed on the stock exchange, questions, inquiries with regards to its accounting in the past so those headlines, at least, possibly weighing on those youku shares in trading today. Back to you. Thank you, dom chu. The snowstorm on the first day of spring got us thinking about all the puddles around the country that need filling. Guess what . Theres a trade for that. The infrastructure stocks that could get a springtime bump plus the dollar demem la. U. S. Stocks battered by the strong greenback. Talk more about the double edge sword of that Going Forward. Do you have something for pain . I have bayer aspirin. Im not having a heart attack, its my back. I mean bayer back body. It works great for pain. Bayer back body provides effective relief for your tough pain. Better . Yeah. Thanks for the tip welcome back to power lunch. Business and Data Information company popping on speculation about a possible takeover. Reuters reporting a consortium of bidders including silver lake among others considering a bid for the company. Ens you see that move in midday trading. Mandy, back to you. That move equates to a percentage of the up side. And nike warning a strong dollar will hurt the current quarter. Darden restaurants up 4 . Other than of olive garden beat the street in the Third Quarter thanks to cost cutting and better than expected sales. A different story for tiffany. Moving to the down side by 3. 3 after the jeweler posted its first Quarterly Sales drop in five years. Im sure the strong dollar may be hurting its tourist Flagship Stores like in new york city as well. Over to you, ty. Mandy, thanks. The calendar says today is the first day of spring burt the weather map tell as different story as we just discussed. Yet another snowstorm coming to the eastern seaboard today and this brutal Winter Weather and record snowfall in many parts of the country resulted in monstersized potholes around the country. On the nations roadways. Many in the northeast. All of which need filled over the next few months, fingers crossed. Where theres pain theres usually profits. Fivestar manager josh deitz run the Infrastructure Fund welcome to power lunch. I cant imagine, frankly, that there is a big profitable stock market play in filling potholes in newton mass or Bergen County new jersey. Theres not. Marginally incremental. Most of contracts of governments . Using aggregates you cant invest in. Those Companies LikeMartin Marietta and vulcan. Buying the material from those manufacturers. Exactly. Your focus is more on the big, broad dekeg infrastructure bridge tunnels. Airports and the like . Absolutely. And where do i make money in that . Completely disrepair of our roads in the United States for instance. And basically the American SocietyCivil Engineers rate our roads with a d. Thats a grade they give us. How do we invest here . A good example is a private company starting to invest in the United States. A company that we own in the Alpine GlobalInfrastructure Fund actually building roads in texas. Theres existing roads, on the expressway and lbj expressway, build additional lanes on the roads and have congestion pricing. Every five minutes they have the ability to change a toll or tearive and the goal keep traffic moving 45 top 50 miles an hounchts will the company own the road . Concession on the road for 50 years in partnership with the dallas fire and chief land. Farovial based where . In spain. Own the Heathrow Airport and toll flowed canada. A great toll road pap 99 year concession on that road and the ability to change tolls as much as they want as long as traffic is quickly, are any of the big cement companies on your buy list or in your fund that you like . So i do like heidelberg cement. A European Company with about 25 of their revenues and profits in the United States. Josh, thank very much. Appreciate it. Thank you. Get home safe. Dont hit any potholes. Tough to avoid. Dont want to ruin the rims. Maybe the money in the infrastructure stocks pay it straight out in car repairs. Right . Yeah. Okay. Dollar dilemma. The gleeback may be on the losing end today but steadily climbing since the middle of last year and its become a double edged sword for the economy. Diving into the dollars impact. Sara eisen, whats the angle youre looking at with this . Mandy, this was a historic and monumental week your currency. The biggest and wildest move seen in years. Plus, comments from the treasury secretary, and the chairman of the Federal Reserve, all on the strength of the u. S. Dollar. Highly unusual. Ill tell you how it will impact the currencys next move. Morgan . The stronger dollar already having an impact on one industry so much so weve actually seen three Different Companies warnings on earnings just this week. Well tell you all about that when power lunch returns. Youre driving along, having a perfectly nice day, when out of nowhere a pickup truck slams into your brand new car. One second it wasnt there and the next second. Boom youve had your first accident. Now you have to make your first claim. 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