I used to love it when i would be in icu and be looking at all the machines and you knew that if it flat lined you had a problem. You just get tired. Youre not in pain. You just get tired. And the next thing i know, a nurse in the icu, a doctor comes in, heres what we have to do for the patient. And they listen to the doctor. Es, right. Any rate, what i was thinking about, carol, is that i believe almost every nurse in the twoyear period who took care of bo showed up and waited as long as five hours in line at wilmington, delaware, to be at his viewing and funeral, which is a hell of a testament to the nurses but also a testament to our children. Look, carol has taken her celebrity and focused it on this fight for a long, long time. And i dont think any of us can thank her enough. Like many of you in this audience, youve given your time, passion, money, to deal with this godawful problem. Dr. Frederick, again, thank you for hosting this summit, for your leadership. Not only is this a Great University but in the medical field its in the fight against cancer, youre part of this whole effort. And as we used to say in the senate a point of personal privilege. Stacy here, who is now i think chairman of the board down here. Its good to see you. I havent seen you in a long, long time. But everything that was ever important or good at home, you were always there. And obviously you havent changed here. You havent changed your stripes in retirement. Let me thank everyone for being here. I want to thank everyone, gathered at more than 260 summit sites in all 50 states, puerto rico, guam, and here in d. C. From miami, florida, to anchorage, alaska, to kentucky, to nebraska, to my hometown of delaware. Summits are being hosted serious undertaking, the department of health and human servicings the American Lung association, the phoenix children hospitals. So many others are hosting summits all across the nation. This was the first time in i believe im told it is the first time that physicians scientists nurses patient advocates, families and cancer survivors, foundations, companies, institutions have all come together at one time in such extremely large numbers throughout the country to simultaneously begin to decide what changes we have to make if any in this fight. All across the country, all under national charge in the white house to do Something Big , very possible, make a decades worth of progress in the next five years. I know, when i first was bhoonshot was first announced naive. D biden is being i believe we can make exponential progress. I firmly believe we can do in the next five years what would ordinarily take ten. And think of what that will mean. Think of how many people you know who are saying, i just want to make it one more month to see my daughter get married. If i can just. If i can just. If i can just make it. I can make it another four months i will be able to pay off u the house and my wife will be ok when i go. All i want to do is see my daughter graduate. These are real, real, real life things. Time matters. Days matter. Minutes matter. Theres nothing antiseptic about any of this. You all know that. We know the problem. Right now there are 14 new million new cases a year in the world, 8. 2 million cancerrelated deaths worldwide per year. The projections are by 2025, if we stay on the exact course we are on now making the progress e are making now there will be o 20 million new cases a year crom 4 million dedses cancer alone. This is preaches to the choir. But unlike other diseases you all know there are over 200 dis tiveraget types of cancer weve identified which makes cancer far more complicated, a far more complicated disease to treat and to understand. Cancer is taking loved ones from us. And when i announced the decision to not run for the president by the way, i learned if you want to become popular announce youre not running for president. If i would known this i would have announced every year i wasnt running. But after bo passed jill and i concluded we couldnt anyway, i said in the announcement, because i was expected to make a formal announcement one way or the other. And it wasnt written on the page. It was spontaneous. I said that my regret is if i could do anything, i would have wanted to be the president who ended cancer as we know it because i think its possible. My mom had the expression, a little bit of knowledge is a dangerous thing. Any time your loved one, someone you care about, someone who is part of your soul, part of who you are, is in trouble, all of you do the same exact thing. You try to learn as much about the thing causes that person trouble. You try to learn as much as you can. Nd i had some great tutors and great hospitals we were in. M. D. Anderson. Jefferson. Walter reed. I had great tutors. That cancer moonshot grew out of a sentiment i acquired that were in the cusp of an awful lot of change. And the United States, after i made that statement, it wasnt planned. It was shortly after the state of the union and the president didnt even tell me but he announced at the state of the union that biden is doing a moonshot. When i first heard it i thought he wanted me to get in the caps sull and head to the moon. He is one of my best friends. But look, he asked me to lead this effort. But he didnt just me to lead it. He gave me authority. Like he did in the recovery act. Authority over all the cabinet positions as if he were doing it to engage the entire federal government, any Cabinet Agency that has any possible impact in the fight against cancer. From outfits like nih to the department of energy. And ive traveled the country and the world touching many of the major Nerve Centers in the fight against cancer to get the ideas of the experts. Is it possible . Can we double the rate at which we make progress . By the way, regardless of where i am, i do an awful lot of Foreign Policy. You know, that old joke, im referred to as the Foreign Policy expert. An expert is anyone from out of town with a briefcase. I didnt bring my briefcase but i must admit i know a lot more about Foreign Policy than i did at the beginning about the fight against cancer. I was recently in the middle east talking about isis and in the gulf with one of the leaders. I thought we were going to have this long discussion and i brought my entire Foreign Policy team, my National Security adviser. He had his whole team sit on this beautiful dock outside one of these palaces. He starts off and he said can we talk about cancer . Can we talk about cancer . When i was in jordan, when i was in israel, japan, south korea, working on mous with each one of those countries, because they want to be part of this effort. Ive been stunned stunned stunned at the response of the president s announcement. Just evidence. Nothing about me or the president. Its about the intensity with which people feel about this subject. And the overwhelming desire to have some concrete hope of additional changes. And everywhere i go when i talk about whats possible in fighting cancer theres a consensus a consensus that weve reached an inflection point. Weve reached let me explain what i mean by that. Five years ago, six years ago, colleges werent routinely working with imnuneologists, vireologists, biological engineers. But now they are. Secondly, theres a recognition by aggregating and sharing data of millions of patients, including genomics, family history, lifestyle, treatment outcomes, we have the potential to find new patterns and causes and successfully treat cancer in ways we never did before. We can now do a thousand billion calculations per second. It changes the world potentially. As to what, with aggregated data, we can learn. Now we have the capability to do it. Advanced technology, super computing allow us to analyze enormous amounts of data to find answers we couldnt do five years ago would take scores and scores of experts. Years pouring over to find similar patterns. And theres new hope, new treatments, more accurate radiation therapies which target cancer cells but do less damages to the healthy cells. Transforming many types of cancers into chronic and manageable diseases when ten years ago they were literally a death sentence. But to view, to seize this moment we have to Work Together and get this all in our reach. One of the biggest problems we have in my view to solve is treatments need to be affordable. We need a strong continuum of generating and using knowledge to fight cancer and we have to change the entire path, in my view, of how knowledge goes from small labs to pharmaceutical companies to production companies. And the cost of life saving drugs is astro noncal. We have to come up with a better way. What is the possible justification when a lifesaving drug is brought to market at the time its brought to market it costs 26,000 a year and 15 years later it costs 120,000 . Tell me. I know there are hundreds of millions of dollars of sunken costs that actually come up with nothing, that have to be accounted for. But i want to raise some questions here and i hope we get some answer. I was committed to bring together all the human financial and Knowledge Resources we have to break down silos to seize the moment and to double our rate of progress but im also committed to doing everything in my power to change the culture that too often stifles that. Quite frankly, we have to change the culture a little bit. In my humble opinion. There was a report in staten news that although nih funding for cancer trials requires when you get the funding, requires the results of that data be reported instantly. The number of institutions that receive the most funding dont report back to nih in a timely fashion. Sometimes a year or more. Nih scientists themselves, 75 of the time, are late or dont report their results. Thats the study. I may be wrong and i hope the experts here will tell me thats incorrect. But under the law it says you must report. If you dont report, the law says you shouldnt get any funding. Im going to find out if its true, and if its true im going to cut funding. Thats a promise. Thats a promise. Because all it does is slow progress. Change the culture. The moonshot effort has a few missions. We have to reclaim the incentive for Research Within the research system. For breakthroughs and faster progress, preventing and treating cancer. We have to change the culture of research that turns scientists into grant writers, discouraging risk taking. We have to change our academic and publicication system to reward teamwork and results for patients not just raw numbers of publicications and awards that are granted. And by the way, i said this to an researchers hosted by organization in one of the other cities. And i noticed the heads of these organizations were a little dismayed when two thirds stood up and clapped. Not a joke. We need to be sure that researchers are also available as soon as they are published so the field can move forward. We have to generate and share and integrate data with the ultimate goal of enhancing patient care. We have to create better systems to share data and to empower patients to share and use their data in the way they want to. In other sectors like physics and aerospace scientists share complex information seemsly and ubiquitously all the time. But somehow i guess for hundreds of years of tradition, not in medicine. Maybe theres explanation. I havent heard it yet. I havent heard it yet. We have to bring new prevention strategy and diagnostics and therapies to communities and places all across the world. The first place im going tomorrow is to cleveland to highlight a Cancer Screening program, a collaboration between George Washington university and case western missouri university. Both washington and cleveland have higher than national than average smoking rates. Lung cancer rites are higher especially in areas where fewer people have access to lung Cancer Screening. This problem uses social media and digital modernizing technologies to help people adapt to healthier lifestyles. You know the numbers beten than i do. Prevention can save a whole hell of a lot more lives than anything we can do. Other screening programs becoming available to help detect cancer early so it can be treatd with better chances of success. These include noninvasive, new genetic markers that allow us to identify those at risk developing cancer long before they develop. Ive been to most every Major Cancer Institution in the country and some of the work theyre doing is absolutely mindblowing. Liquid biopsies. Getting a whole lot of attention and may provide an even better way to screen for cancer very early in the process, with a simple blood test. We can reach more people by taking the screening into their Communities Just like we did, i might add, with Breast Cancer and hiv and we have mobile vans rolling into all those communities. You helped set up in wilmington making sure we have a large we have a large African American population that was underserved. We have mobile vans roll in. As these techniques become more and more available and more precise, theres a lot we can do. Finally, we have to accelerate getting treatments to patients by identifying any unnecessary regulatory barriers that exist at the federal level that stand in the way of improving researcher care. For example, patients should be able to seamlessly find a Clinical Trial that might suit a specific condition. Doctors should have anize way of guiding their patients through the process. But less than, as you all know, 4 that enroll in trials that might be key to discovering the next lifesaving treatment. Ive been in nevada, california, florida. Ive been to i think 11 of the most highly funded and reputable Cancer Centers in the world and they talk about how can they get, how will they be able to get this lifesaving capacity out to rural communities, indian reservations . He one thing about you docs is you became doctors for a reason. Youre devoted. You care. You care a heck of a lot. And it surprised me and pleased me to see how intensely the medical community is talking about the need to get services to atrisk communities that werent available right now. On line critical excuse me. On line Clinical Data base has proven to be far too complicated for most patients and most local oncologists to be able to navigate. Under the moonshot weve created the new trials. Cancer. Gov to help people learn about and get access to cancer trials which will also be i hope a significant benefit to the pharmaceutical companies who are conducting trials and many times trouble finding enough people to be in the trials. That we cant come up with a map that is accurately able to be used that has this data is surprising to me. I was my son and its not about my son. My personal experience. We put in the recovery act which the president asked me to manage over almost 1 trillion. And by the way with every outside study less than 2 10 waste or fraud. In that we thought we were going to change the way we covered and we thought electronic Record Keeping would help a great deal. It all got spent. Guess what, the five systems cant talk to one another. Think about it. Now, were not computer scientists. My son bo had allegedly he was in a trial of one, antipd 1 and a viral injected into stage 4 gleeo blast oma requiring him to on a multiple times during the day do an mri to see the progress. At first the doctors were giddy at the progress that was being made. But he was up at walter reed md the doctors were down at anderson. An incredible organization, in my view. But for the fact my son inlaw is a leading surgeon in the philadelphia area, we had to gather up the information not recorded, get in a plane and fly it down. Joe, can you imagine your company functioning that way and being able to make it . Its not anybodys fault. But weve got to fix it. Weve got to fix it. We owe it to future generations to seize this moment to move with deliberate purpose and double our rate of progress by just doing things that if this were a hightech firm we were running they would say weve got to solve this problem. Its within our wheelhouse to do these things. What im talking about so far doesnt even contemplate the enormous genius that resides in this room. Like one of the brightest men in all of medicines the guy sitting right there who is the head of nih. I mean it sincerely. The impediment isnt the lack of the gray matter genius and ingenuity in terms of new drugs, new treatments, et cetera. Its all this stuff that gets in the way. The only thing im good at in government is getting things out of the way. No, no. I am good at that. [applause] i am good at that. So i dont want this to come across as somehow the federal government has the answer. We dont have the answers. Weve got to figure out how to get out of your way and you guys have to figure out how to et in each others way more. Previous generations have successfully faced similar problems and given us longer lives and millions of people fear that their children during polio epidemic in the 50s. But hope conquered here sooner than anyone could imagine with technology and breakthroughs with the polio vaccine. Look what yeah all have done with hiv aids and how youve aggregated capability and the progress thats made. Cancer is not going to be conquered by any one thing but i believe its a challenge, with your brilliance, we can win if were devoted to winning it in a timely fashion, meaning yesterday. Today were announcing a series of measures being implemented by government agencies, universities, institutions and foundations that address some of the problems and move us toward a goal of doubling that rate of progress. The federal task force has gotten to work and today is announcing a dozen new actions or policies including the department of energy and Veterans Affairs have now formed a collaboration to apply the most powerful comptational assets at the National Labs to nearly half a million veterans records in one of the Worlds Largest research cohorts. The million veteran program. A cornerstone in the president s Precision Medicine initiative. The National Institute