Vaccine Efficacy According to the latest data from the Centers for Disease Control, the efficacy rate of the Pfizer vaccine is 95 percent, the Moderna is at 90 percent and the Johnson and Johnson vaccine ranges from 66 to 72 percent depending on its use globally and in the U.S. Tuesday, the CDC and FDA recommended the temporary pause of the J&J vaccine due to a small number of cases of a rare and severe type of blood clot that has been reported in people who’ve received the one-shot vaccine. State Health Officer Dr. Alexia Harrist talks about the expedited process that was used in developing the COVID vaccines.