In 2007, The Sopranos was a hit TV show, patterned jeggings were a fashion trend, and the National Institutes of Health–sponsored National Asthma Education and Prevention Program (NAEPP) published the second edition of the Asthma Management Guidelines. A lot has changed since 2007, including in the area of asthma. The NAEPP recently published the third edition of the Asthma Management Guidelines to address these changes. This update reflects recent advances in our understanding of the disease mechanisms causing asthma, and the current best practices to manage asthma symptoms. As such, the updated guidelines are an important tool, enhancing the ability of physicians and patients to control asthma and minimize the impact of this disease on their lives.