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Combination Therapy & Radiation Holds Promise in Glioblastoma


Combination Therapy & Radiation Holds Promise in Glioblastoma
by Angela Mohan on 
February 10, 2021 at 2:14 PM
Anti-psychotic drug and a statin combination along with radiation improves the overall survival in mice with glioblastoma, as per the study done on mice by the team of researchers at the UCLA Jonsson Comprehensive Cancer Center.
Glioblastoma is one of the deadliest and most difficult-to-treat brain tumors. Researchers found the triple combination extended the median survival 4-fold compared to radiation alone.
Radiation therapy is part of the standard-of-care treatment regimen for glioblastoma, often helping prolong the survival of patients. However, survival times have not improved significantly over the past two decades and attempts to improve the efficacy of radiotherapy through the use of pharmaceuticals have been hampered by the normal tissue toxicity of the drugs and the inability to penetrate the blood-brain barrier. ....

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Brian Eno's diary proves anything but minimalist | Music


A Year With Swollen Appendices: Brian Eno’s Diary. Praised by
The Guardian as one of the seminal books about music, the long out-of-print work was republished this week by Faber and Faber in a strikingly beautiful hardcover edition that weighs in at a hefty 1.22 pounds and falls just short of 500 pages.
When asked to write an introduction for the anniversary edition, Eno did the sort of thing you’d expect him to do. “I started out by making a list of new words — ideas that either didn’t exist or weren’t in the air when I wrote the diary.” ....

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The Lab Report: Improving immunotherapy for cancer patients by braking inhibitors · The Badger Herald


T-Cells are cells in the immune system that, when bound to the CD28 receptor, can be activated to attack a certain structure in the body, according to Onate. The body uses CTLA-4 to compete with CD28 for the T-cells, so they don’t harm healthy cells.
One angle of attack for in situ vaccination uses Anti-CTLA-4 inhibitors to activate the immune system to target cancer cells, Onate said. Anti-CTLA-4 inhibitors deactivate CTLA-4 so more T-cells may be activated to cause an immune response at the site of the tumor.
“If CTLA are the brakes of the immune system, this is like putting the brakes on the brakes,” Onate said. “It inhibits the inhibitor.” ....

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FCC sued for dismissing evidence that wireless technology can have serious effects on health


Federal Communications Commission (FCC) was sued by two health advocacy organizations over the agency’s “capricious, arbitrary and not evidence-based” refusal to acknowledge that wireless technology devices and infrastructure, such as cell towers and smartphones, can have serious health effects.
On Monday, Jan. 25, attorneys for the Children’s Health Defense (CHD) and the Environmental Health Trust (EHT) presented oral arguments before the 
Court of Appeals for the District of Columbia Circuit challenging the support of the FCC for keeping radiofrequency levels the same.
The CHD’s and EHT’s oral arguments against the FCC also attacked the agency’s support for the telecommunications industry’s long-term effort to impose 5G wireless technology on American consumers. ....

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