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Distinct Parkinson's Disease Symptoms Tied to Different Brain Pathways

Distinct Parkinsonâs Disease Symptoms Tied to Different Brain Pathways
Identification of neural circuits clarifies motor vs. cognitive symptoms, aiding efforts to improve treatments
Lim Lab, UC San Diego
A three-dimensional rendering of a mouse hemisphere shows brain-wide projection patterns of GPe neurons labeled by mRuby2 (soma, axonal fibers) and eGFP (pre-synaptic sites).
Newswise Parkinson’s disease (PD) is well known as a debilitating disease that gradually worsens over time. Although the disease’s progression has been largely tied to the loss of motor functions, non-motor symptoms, including the loss of cognitive abilities, often emerge early in the disease.
Much less understood is the role that specific neural circuits play in these distinct motor and non-motor functions. ....

Horia Pribiag , Christopher Dabin Yoon , Eric Hou Jen Wang , Kwanghun Chung , Amanda Ngoc Tran , Jun Hyeok Choi , Xiao Yun Wang , Varoth Lilascharoen , Stefan Carl Pate , Anandamahidol Foundation Fellowship , University Of California San Diego , National Institutes Of Health , California San Diego , Nature Neuroscience , Neurobiology Section , Biological Sciences , Young Gyun Park , National Institutes , Brain Neurons Basal Ganglia Parkinsons Disease Neural Circuit Mapping Behavior Pathways , All Journal News , Parkinsons Disease , National Institutes Of Health Nih , எரிக் ஹூ ஜென் வாங் , அமண்டா ந்காக் டிரான் , கிஷியஓ யுன் வாங் , ஸ்டீபன் கார்ல் பட்டே ,

An interactive visual database for American Sign Language reveals how signs are organized in the mind

“Desire” and “still” don’t rhyme in English, but they do rhyme in American Sign Language. Just as poets can evoke emotions and meaning by choosing words that echo one another in English, actress and Tony nominee Lauren Ridloff chooses signs that visually echo one another in her ASL adaptation of Anne Michaels’ poem “Not.”
For spoken languages, there are many resources that contain information about how often words are used, which words rhyme and other information not found in a dictionary. But until recently, there was no such thing for sign languages.
We are four researchers who study psycholinguistics, linguistics, neuroscience and deaf education. Our team of deaf and hearing scientists worked with a group of software engineers to create the ASL-LEX database that anyone can use for free. We cataloged information on nearly 3,000 signs and built a visual, searchable and interactive database that allows scientists and linguists to work with ASL in entirely ....

United States , Lauren Ridloff , Anne Michael , American Sign , Zed Sevcikova Sehyr , Cavan Images , American Sign Language , Sign Language , Data Base , ஒன்றுபட்டது மாநிலங்களில் , அன்னே மைக்கேல் , அமெரிக்கன் அடையாளம் , கேவன் படங்கள் , அமெரிக்கன் அடையாளம் மொழி , அடையாளம் மொழி , தகவல்கள் அடித்தளம் ,

Cleaning dummies with chemicals may increase risk of food allergies, study warns

Cleaning dummies with chemicals may increase risk of food allergies, study warns
9news.com.au - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from 9news.com.au Daily Mail and Mail on Sunday newspapers.

Anne Louise Ponsonby , Mental Health , Florey Institute Of Neuro Science , Florey Institute , Barwon Infant Study , மன ஆரோக்கியம் , மிதவை நிறுவனம் ஆஃப் நரம்பியல் அறிவியல் , மிதவை நிறுவனம் , பார்வோன் குழந்தை படிப்பு ,

Ashok Soota launches SKAN Medical research trust for Ageing and Neurological disorders, Commits Rs. 200 Cr investment

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BENGALURU, India, April 5, 2021 /PRNewswire/ Ashok Soota today announced the creation of SKAN, probably India s first not-for-profit entity in the private sector, exclusively for medical research.
The research for the projects will be done through reputed partners, and directly in-house. The strategic partner for Neurological research is the Centre for Brain Research (CBR) at Indian Institute Science, Bangalore (IISc). CBR is putting together a consortium to handle the first project on Parkinson s disease. The strategic partner for Ageing is the upcoming St. John s Geriatric Centre (SJGC), to be located on the St John s Hospital campus. Soota has agreed to fund the setting up of the Centre for Research in Ageing and Geriatrics (CRAG) at the SJGC and to support joint projects. In Ageing, the approach will be to go wide into relatively under-researched areas and will include the establishment of a large community-based research cohort. For Neurological research, the pl ....

Kostenloser Wertpapierhandel , Ashok Soota , Prnewswire Ashok Soota , Indian Institute Science , Centre For Research , John Geriatric Centre , Centre For Brain Research , Brain Research , Geriatric Centre , Happiest Minds , Medi Cal , இந்தியன் நிறுவனம் அறிவியல் , மையம் க்கு ஆராய்ச்சி , ஜான் வயதான மையம் , மையம் க்கு மூளை ஆராய்ச்சி , மூளை ஆராய்ச்சி , வயதான மையம் , மகிழ்ச்சியான மனங்கள் , மேதி கலோரி ,

New blueprint of brain connections reveals extensive reach of central regulator

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IMAGE: Shown here in green are branches, or axons, from cells in the substantia nigra region that connect to the midbrain. Red spots label where cells connect.
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Credit: Lauren McElvain / Kleinfeld lab / UC San Diego)
Thousands of our daily activities, from making coffee to taking a walk to saying hello to a neighbor, are made possible through an ancient collection of brain structures tucked away near the center of the cranium.
The cluster of neurons known as the basal ganglia is a central hub for regulating a vast array of routine motor and behavior functions. But when signaling in the basal ganglia is weakened or broken, debilitating movement and psychiatric disorders can emerge, including Parkinson s disease, Tourette s syndrome, attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder. ....

United States , Yuncong Chen , Johnj Ngai , Brenda Bloodgood , Lauren Mcelvain , G Stefano Brigidi , Neurophysics Laboratory Of Professor David Kleinfeld , National Institutes Of Health , Zuckerman Institute Principal Investigator Rui Costa , Brain Research , Division Of Biological Sciences Section Neurobiology , Columbia Vagelos College Of Physicians , University Of Utah School Medicine , University Of California San Diego , Tourette Association Of America , Division Of Physical Sciences Department Physics , European Research Council , Zuckerman Institute , Columbia University Zuckerman Institute , Howard Hughes Medical Institute , California San Diego , Columbia University , Assistant Project Scientist Lauren Mcelvain , Neurophysics Laboratory , Professor David Kleinfeld , Advancing Innovative Neurotechnologies ,