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Mouse models of neurodevelopmental disorders display metabolic dysfunction

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IMAGE: A new study using mouse models of neurodevelopmental disorders identifies alterations in energy metabolism that are sex-specific and distinct between models. These findings point to novel peripheral anomalies and force.
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Credit: Illustration by Baptiste Lacoste. Created with BioRender.com
Mouse models of neurodevelopmental disorders possess unique, sex-specific metabolic dysfunctions, according to a new study in
eNeuro. Understanding the unique metabolic effects of each disorder in both animal models and humans may lead to more personalized treatments and diagnostic methods.
Any disorder affecting the brain also impacts the body. People with neurodevelopmental disorders including Down syndrome and autism spectrum disorders are at increased risk for developing diabetes, obesity, and hypertension. Yet the impact of these three disorders on metabolism has not been studied. ....

Society For Neuroscience , Distinct Basal Metabolism , Three Mouse Models , Nutrition Nutrients , Medicine Health , Diet Body Weight , Metabolism Metabolic Diseases , சமூகம் க்கு நரம்பியல் , தனித்துவமானது அடித்தளம் வளர்சிதை மாற்றம் , மூன்று சுட்டி மாதிரிகள் , ஊட்டச்சத்து ஊட்டச்சத்துக்கள் , மருந்து ஆரோக்கியம் , உணவு உடல் எடை , வளர்சிதை மாற்றம் வளர்சிதை மாற்ற நோய்கள் ,

Understanding how cancer can relapse

Credit: University of Missouri
In the fight against cancers, activating mutations in the RAS family of genes stand in the way of finding viable treatment options. Now, scientists at the University of Missouri and Yale University have discovered that one of these mutations oncogenic RAS or RASV12 is also responsible for the regrowth of cancer cells following genotoxic therapy treatment, or drugs that cause damage to a cancer cell s DNA in order to eliminate it from the body.
Most of our knowledge of how cells respond to DNA damage is mainly derived from studies looking at the single cell level, said Yves Chabu, an assistant professor in the MU College of Arts and Science. Therefore, we don t know much about how tumor cells respond to DNA damage in the broader context of the tissue level, and what possible implications these responses might have on a tumor s relapse following genotoxic therapies. To address this, we looked at how tissues containing patches of cell ....

Yves Chabu , Yale University , Nature Research , National Cancer Institute , Division Of Biological Sciences , University Of Missouri , Communications Biology , Mu College Of Arts , Howard Hughes Medical Institute , National Cancer , Cell Biology , Molecular Biology , Internal Medicine , யேல் பல்கலைக்கழகம் , இயற்கை ஆராய்ச்சி , தேசிய புற்றுநோய் நிறுவனம் , பிரிவு ஆஃப் உயிரியல் அறிவியல் , பல்கலைக்கழகம் ஆஃப் மிச Ou ரி , தகவல்தொடர்புகள் உயிரியல் , மு கல்லூரி ஆஃப் கலைகள் , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் , தேசிய புற்றுநோய் , செல் உயிரியல் , மூலக்கூறு உயிரியல் , உள் மருந்து ,

Scientists use a novel two-step method to track receptor proteins

Scientists use a novel two-step method to track receptor proteins
The neurons in our nervous system talk to each other by sending and receiving chemical messages called neurotransmitters. This communication is facilitated by cell membrane proteins called receptors, which pick up neurotransmitters and relay them across cells. In a recent study published in
Nature Communications, scientists from Japan report their findings on the dynamics of receptors, which can enable understanding of the processes of memory formation and learning.
The regulation of receptor movement and localization within the neuron is important for synaptic plasticity, an important process in the central nervous system. A specific type of glutamate receptor, known as AMPA-type glutamate receptor (AMPAR), undergoes a constant cycle of trafficking , being cycled in and out of the neuronal membrane. A precise regulation of this trafficking process is associated with learning, memory formation, an ....

Shigeki Kiyonaka , Emily Henderson , Nature Communications , Nagoya University , Kyoto University , Keio University , Professor Shigeki Kiyonaka , Cell Membrane , Central Nervous System , Nervous System , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , நாகோயா பல்கலைக்கழகம் , கியோட்டோ பல்கலைக்கழகம் , கேோ பல்கலைக்கழகம் , செல் சவ்வு , மைய பதட்டமாக அமைப்பு , பதட்டமாக அமைப்பு ,

Welcome To IANS Live - BUSINESS - Soota commits Rs 200 cr for medical research centre in B'luru

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Bengaluru, April 4 (IANS) Serial entrepreneur Ashok Soota on Sunday announced Rs 200 crore funding to set up Skan medical research trust here for ageing and neurological disorders.
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Update: 04-April-2021 ....

News Service , India Private , Ashok Soota , All Rights , செய்தி சேவை , இந்தியா ப்ரைவேட் , அனைத்தும் உரிமைகள் ,

First-of-its-kind study identifies 13 new Alzheimer's disease genes

First-of-its-kind study identifies 13 new Alzheimer’s disease genes
In the first study to use whole genome sequencing (WGS) to discover rare genomic variants associated with Alzheimer s disease (AD), researchers have identified 13 such variants (or mutations). In another novel finding, this study establishes new genetic links between AD and the function of synapses, which are the junctions that transmit information between neurons, and neuroplasticity, or the ability of neurons to reorganize the brain s neural network. These discoveries could help guide development of new therapies for this devastating neurological condition.
Researchers at Massachusetts General Hospital (MGH), the Harvard T. H. Chan School of Public Health, and Beth Israel Deaconess Medical Center report these findings in ....

United States , Rudolph Tanzi , Dmitry Prokopenko , Emily Henderson , Research Unit , Beth Israel Deaconess Medical Center , Mccance Center , Journal Of The Alzheimer Association , Brain Health , Massachusetts General Hospital , Chan School , Public Health , Aging Research , Cance Center , Alzheimer 39s Disease , Medical School , Whole Genome Sequencing , ஒன்றுபட்டது மாநிலங்களில் , ருடால்ப் டான்சி , எமிலி ஹென்டர்சன் , ஆராய்ச்சி அலகு , பெத் இஸ்ரேல் டேப்ககோணேஸ் மருத்துவ மையம் , ம்க்க்யாந்ஸ் மையம் , இதழ் ஆஃப் தி முதுமறதி சங்கம் , மூளை ஆரோக்கியம் , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை ,