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SARS-CoV-2 spike mutation can independently predict viral evolution


SARS-CoV-2 spike mutation can independently predict viral evolution
A team of scientists from Portugal has recently estimated the rate of mutation in two circulating variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using experimental evolution methods. Their findings reveal that in a condition with no immune surveillance, SARS-CoV-2 can potentially undergo evolution during the first stages of infection. The study is currently available on the
Background
The acquisition of mutations is the primary driving force for viral evolution. The predictability of viral evolution can be assessed by estimating the rate of genomic mutations. DNA viruses generally exhibit a constant mutation rate, while RNA viruses vary widely in mutation rate. In pathogens, mutations are originated in response to selection pressures, including therapeutics, cell types, and host immune responses. During viral lifecycle, a gradual accumulation of mutations under positive selec ....

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