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New targeted therapy provides survival benefit in KRAS G12C-mutated lung cancer

Results From Phase 2 CodeBreaK 100 Show LUMAKRAS Is The First And Only KRAS G12C Inhibitor With Overall Survival Data

Amgen today presented data on overall survival, a secondary endpoint, from the Phase 2 results of the CodeBreaK 100 clinical study for LUMAKRAS TM  in previously treated patients with non-small cell lung cancer during the 2021 American Society of Clinical Oncology Annual Meeting. These data were also simultaneously published in the New England Journal of Medicine . The publication includes mature overall . ....

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BeyondSpring Announces First Patient Dosed in a Triple Combination Study with Plinabulin, PD-1/PD-L1 Inhibitor and Radiotherapy for the Reversal of Resistance to PD-1/PD-L1 Inhibitors in Patients with Advanced Solid Tumors


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Resistance to immunotherapy is a severe unmet medical need that plinabulin aims to address in combination with checkpoint inhibitors and radiotherapy
First patient who failed Keytruda and chemotherapy has been dosed with plinabulin, Keytruda and radiation combination in non-small cell lung cancer (NSCLC)
NEW YORK, June 04, 2021 (GLOBE NEWSWIRE) BeyondSpring (the “Company” or “BeyondSpring”) (NASDAQ: BYSI), a global biopharmaceutical company focused on the development of innovative cancer therapies, today announced that the first patient had been dosed in the Phase 1b/2 investigator-initiated trial, studying the safety and tolerability of plinabulin, in triple combination therapy with both PD-1/PD-L1 antibody (mAb) and radiation therapy (RT). This triple combination is actively recruiting at The University of Texas MD Anderson Cancer Center, with Dr. Vivek Subbiah as principal investigator, in seven metastatic or locally advanc ....

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