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Antiviral T cells safe, effective as off-the-shelf therapy for painful complication after stem cell transplants

Antiviral T cells safe, effective as off-the-shelf therapy for painful complication after stem cell transplants
A Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center found that BK virus (BKV)-specific T cells from healthy donors were safe and effective as an off-the-shelf therapy for BKV-associated hemorrhagic cystitis (BKV-HC), a painful complication common after allogeneic stem cell transplants for patients with leukemia or lymphoma. The study was published today in the
Journal of Clinical Oncology.
Infusion of T cells targeting BKV resulted in rapid responses, with 67.7% of patients seeing a complete or partial improvement in symptoms after 14 days. This increased to 81.6% of patients after 28 days post-infusion. No cases of grade 3 or grade 4 graft versus host disease (GVHD) or other infusion-related toxicities occurred. ....

United States , Katy Rezvani , Elizabethj Shpall , Emily Henderson , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Moon Shots Program , Cancer Center , Corresponding Author , Stem Cell Transplantation , New England Journal , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , நிலா காட்சிகளை ப்ரோக்ர்யாம் , புற்றுநோய் மையம் , தண்டு செல் மாற்று அறுவை சிகிச்சை , புதியது இங்கிலாந்து இதழ் , தேசிய நிறுவனங்கள் ,

Mereo BioPharma and Cancer Focus Fund Announce Partnership for Phase 1b/2 Study of Etigilimab in Clear Cell Ovarian Cancer

Mereo BioPharma and Cancer Focus Fund Announce Partnership for Phase 1b/2 Study of Etigilimab in Clear Cell Ovarian Cancer
streetinsider.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from streetinsider.com Daily Mail and Mail on Sunday newspapers.

United States , City Of , United Kingdom , Shannon Westin , Ross Barrett , Denise Scots Knight , Mereo Biopharmamereo Biopharma , Christine Fox , Barbara Lindheim , Lee Roth , Clayton Boldt , Cancer Focus Fund , Cancer Focus Fund Contact , Ultragenyx Pharmaceutical Inc , University Of Texas Md Anderson Cancer Center , Mereo Biopharma Group , Feist Weiller Cancer Center Shreveport , Oncologie Inc , Oncxerna Therapeutics Inc , United States Securities Exchange , Partner Of Cancer Focus Fund , Partners For Cancer Focus Fund , Md Anderson Institutional Conflict Of Interest Committee , Cancer Focus Fundthe Fund , Biopharma Group , Cancer Center ,

Mereo BioPharma and Cancer Focus Fund Announce Partnership for Phase 1b/2 Study of Etigilimab in Clear Cell Ovarian CancerStudy to be Conducted at The University of Texas MD Anderson Cancer Center

Published: Apr 30, 2021
LONDON and REDWOOD CITY, Calif. and HOUSTON, Texas, April 30, 2021 (GLOBE NEWSWIRE) Mereo BioPharma Group plc (NASDAQ: MREO) (“Mereo” or the “Company”), a clinical-stage biopharmaceutical company focused on oncology and rare diseases, and Cancer Focus Fund, LP, a unique venture capital fund established in collaboration with The University of Texas MD Anderson Cancer Center (“MD Anderson”) to provide funding and clinical expertise to advance promising cancer therapies, today announced a partnership to evaluate Mereo’s lead anti-TIGIT therapeutic antibody candidate, etigilimab, in clear cell ovarian cancer, a rare cancer that accounts for approximately 5–10% of all ovarian carcinomas in North America. ....

United States , City Of , United Kingdom , Shannon Westin , Ross Barrett , Denise Scots Knight , Mereo Biopharma , Christine Fox , Barbara Lindheim , Lee Roth , Clayton Boldt , Cancer Focus Fund , Cancer Focus Fund Contact , Ultragenyx Pharmaceutical Inc , University Of Texas Md Anderson Cancer Center , Mereo Biopharma Group , Feist Weiller Cancer Center Shreveport , Oncologie Inc , Oncxerna Therapeutics Inc , United States Securities Exchange , Partner Of Cancer Focus Fund , Partners For Cancer Focus Fund , Md Anderson Institutional Conflict Of Interest Committee , Biopharma Group , Cancer Center , Gynecologic Oncology ,

(MREO) - Cancer Focus Fund To Finance Mereo's Ovarian Cancer Study With Etigilimab

(MREO) - Cancer Focus Fund To Finance Mereo's Ovarian Cancer Study With Etigilimab
benzinga.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from benzinga.com Daily Mail and Mail on Sunday newspapers.

United States , Cancer Focus Fund , University Of Texas Md Anderson Cancer Center , Mereo Biopharma Group , Cancer Center , Focus Fund , ஒன்றுபட்டது மாநிலங்களில் , புற்றுநோய் கவனம் நிதி , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , புற்றுநோய் மையம் , கவனம் நிதி ,

Antiviral T cells safe and effective for treating debilitating complication common after stem cell transplants

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HOUSTON ? A Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center found that BK virus (BKV)-specific T cells from healthy donors were safe and effective as an off-the-shelf therapy for BKV-associated hemorrhagic cystitis (BKV-HC), a painful complication common after allogeneic stem cell transplants for patients with leukemia or lymphoma. The study was published today in the
Journal of Clinical Oncology.
Infusion of T cells targeting BKV resulted in rapid responses, with 67.7% of patients seeing a complete or partial improvement in symptoms after 14 days. This increased to 81.6% of patients after 28 days post-infusion. No cases of grade 3 or grade 4 graft versus host disease (GVHD) or other infusion-related toxicities occurred. ....

United States , Katy Rezvani , Elizabethj Shpall , University Of Texas Md Anderson Cancer Center , National Institutes Of Health , Moon Shots Program , Cancer Center , Stem Cell Transplantation , New England Journal , National Institutes , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , நிலா காட்சிகளை ப்ரோக்ர்யாம் , புற்றுநோய் மையம் , தண்டு செல் மாற்று அறுவை சிகிச்சை , புதியது இங்கிலாந்து இதழ் , தேசிய நிறுவனங்கள் ,