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CNS Pharmaceuticals Berubicin Trial is On Schedule to Commence in March 2021


CNS Pharmaceuticals Berubicin Trial is On Schedule to Commence in March 2021
Potentially pivotal study evaluating efficacy of Berubicin in the treatment of adult Glioblastoma Multiforme (GBM), one of the most aggressive types of brain cancer
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 (NASDAQ: CNSP) ( CNS or the Company ), a biopharmaceutical company specializing in the development of novel treatments for primary and metastatic cancers of the brain and central nervous system, today indicated that the clinical program for Berubicin is on track to start enrolling patients in March 2021. CNS lead product candidate, Berubicin, is a novel anthracycline and the first anthracycline to cross the blood-brain barrier. It is in development for the treatment of a number of serious brain and CNS oncology indications. ....

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Neoadjuvant combination immunotherapy improves outcomes for early stage non-small cell lung cancer


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Neoadjuvant combination immunotherapy improves outcomes for early stage non-small cell lung cancer
The first randomized Phase II clinical trial to report on single and combined neoadjuvant immune checkpoint inhibitor therapy in stage I-III non-small cell lung cancer (NSCLC) found combination therapy produced a significant clinical benefit, as assessed by major pathologic response (MPR) rate, as well as enhanced tumor immune cell infiltration and immunological memory. Researchers from The University of Texas MD Anderson Cancer Center published the study results today in Nature Medicine.
The NEOSTAR trial tested combined neoadjuvant therapy of nivolumab plus ipilimumab, as well as neoadjuvant nivolumab monotherapy in patients with operable NSCLC. The trial met its prespecified primary endpoint efficacy threshold in the combination arm, with eight of 21 treated patients (38%) achieving major pathological response, defined as ≤10% viable tumor at surgery. MPR h ....

United States , Boris Sepesi , Tina Cascone , Bob Mayberry Foundation , University Of Texas Md Anderson Cancer Center , National Institutes Of Health Cancer Institute , Connie Rasor Endowment For Cancer Research , Md Anderson Moon Shots Program , Md Anderson Physician Scientist Program , Rexanna Foundation For Fighting Lung Cancer , Bristol Myers Squibb , Translation Molecular Profiling Laboratory , Khalifa Bin Zayed Al Nahyan Foundation , Cancer Center , Neck Medical Oncology , Lung Cancer Moon , Cardiovascular Surgery , National Institutes , National Cancer Institute , American Society , Clinical Oncology , Connie Rasor Endowment , Cancer Research , Bruton Endowed Chair , Tumor Biology , Physician Scientist Program ,