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Outcomes Improved in Lung Cancer Patients with Dual Immunotherapy & Chemotherapy

Outcomes Improved in Lung Cancer Patients with Dual Immunotherapy & Chemotherapy
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United States , David Bruton Jr , Tina Cascone , Andrew Sabin Family Foundation , Bob Mayberry Foundation , University Of Texas Md Anderson Cancer Center , Connie Rasor Endowment For Cancer Research , Bristol Myers Squibb Company , Md Anderson Moon Shots Program , Md Anderson Physician Scientist Program , Rexanna Foundation For Fighting Lung Cancer , National Institute Of Health Cancer , Translation Molecular Profiling Laboratory , Khalifa Bin Zayed Al Nahyan Foundation , Cancer Center , Nature Medicine , Neck Medical , Bristol Myers Squibb , Lung Cancer Moon , National Institute , National Cancer Institute , American Society , Clinical Oncology , Connie Rasor Endowment , Cancer Research , David Bruton ,

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
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United States , Baylor College Of Medicine , University Of Texas , Roche Genentech , Prolacta Biosciences , Fulbright Franco , Bristol Myers Squibb , Sj Javornik Cregeen , Venn Biosciences , John Mendelsohn , Castle Biosciences , Institut Gustav Roussy , Richarde Haynes , Johnm Skibber , Liscure Biosciences , Reata Pharmaceuticals , National Cancer Institute Center , Department Of Defense , Md Anderson Cancer Center , Us Israel Binational Science Foundation , Charlesa King Trust Postdoctoral Research Fellowship , Research Institute Of Texas Training Program , Mark Foundation , Melanoma Foundation , American Association For The Advancement Of Science , Patricia Melanoma Research Endowment ,

Neoadjuvant combination immunotherapy improves outcomes for early stage non-small cell lung cancer

Date Time
Neoadjuvant combination immunotherapy improves outcomes for early stage non-small cell lung cancer
The first randomized Phase II clinical trial to report on single and combined neoadjuvant immune checkpoint inhibitor therapy in stage I-III non-small cell lung cancer (NSCLC) found combination therapy produced a significant clinical benefit, as assessed by major pathologic response (MPR) rate, as well as enhanced tumor immune cell infiltration and immunological memory. Researchers from The University of Texas MD Anderson Cancer Center published the study results today in Nature Medicine.
The NEOSTAR trial tested combined neoadjuvant therapy of nivolumab plus ipilimumab, as well as neoadjuvant nivolumab monotherapy in patients with operable NSCLC. The trial met its prespecified primary endpoint efficacy threshold in the combination arm, with eight of 21 treated patients (38%) achieving major pathological response, defined as ≤10% viable tumor at surgery. MPR h ....

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