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Proteogenomics offers insight to treating head and neck squamous cell carcinoma


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HOUSTON - (Jan. 7, 2021) - Proteogenomic analysis may offer new insight into matching cancer patients with an effective therapy for their particular cancer. A new study identifies three molecular subtypes in head and neck squamous cell carcinoma (HNSCC) that could be used to better determine appropriate treatment. The research led by Baylor College of Medicine, Johns Hopkins University and the National Cancer Institute s Clinical Proteomic Tumor Analysis Consortium (CPTAC) is published in the journal
Cancer Cell.
Researchers profiled proteins, phosphosites and signaling pathways in 108 human papillomavirus-negative HNSCC tumors in order to understand how genetic aberrations drive tumor behavior and response to therapies. Currently, there are a few FDA-approved therapies for HNSCC, including an epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) inhibitor and two PD-1 inhibitors, but response rates are moderate. In this study, researchers aimed t ....

Baylor College Of Medicine , United States , Danielw Chan , Bing Zhang , Johns Hopkins University , Mcnair Medical Institute , National Cancer Institute , Janice Mcnair Foundation , Translational Breast Cancer Research Training Program , Clinical Proteomic Tumor Analysis Consortium , Johns Hopkins University School Of Medicine , Cancer Prevention Research Institute Of Texas , Sue Smith Breast Center , Department Of Molecular , Danl Duncan Comprehensive Cancer Center , Cancer Prevention Institute Of Texas , Baylor College , Human Genetics , Cancer Prevention , Research Institute , Mcnair Scholar , Biomarker Discovery , Johns Hopkins University School , Cancer Prevention Institute , Janice Mcnair , பேலர் கல்லூரி ஆஃப் மருந்து ,

Mediterranean diet may decrease risk of prostate cancer progression


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In a study to examine a Mediterranean diet in relation to prostate cancer progression in men on active surveillance, researchers from The University of Texas MD Anderson Cancer Center found that men with localized prostate cancer who reported a baseline dietary pattern that more closely follows the key principles of a Mediterranean-style diet fared better over the course of their disease.
Men with prostate cancer are motivated to find a way to impact the advancement of their disease and improve their quality of life, said Justin Gregg, M.D., assistant professor of Urology and lead author of the study, published today in ....

United States , Carrie Daniel Macdougall , Justin Gregg , Research Training Award For Cancer Prevention , Training Program In Integrative Epidemiology , University Of Texas Md Anderson Cancer Center , National Cancer Institute Center Support Grant , Cancer Prevention Research Institute Of Texas , Cancer Center , African American , Research Training Award , Cancer Prevention Post Graduate Training Program , Integrative Epidemiology , Cancer Prevention , Research Institute , ஒன்றுபட்டது மாநிலங்களில் , கேரி டேனியல் மக்டூகல் , ஜஸ்டின் க்ரெக் , ஆராய்ச்சி பயிற்சி விருது க்கு புற்றுநோய் ப்ரெவெந்ஶந் , பயிற்சி ப்ரோக்ர்யாம் இல் ஒருங்கிணைந்த தொற்றுநோய் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , தேசிய புற்றுநோய் நிறுவனம் மையம் ஆதரவு மானியம் , புற்றுநோய் ப்ரெவெந்ஶந் ஆராய்ச்சி நிறுவனம் ஆஃப் டெக்சாஸ் , புற்றுநோய் மையம் , ஆராய்ச்சி பயிற்சி விருது , புற்றுநோய் ப்ரெவெந்ஶந் போஸ்ட் பட்டதாரி பயிற்சி ப்ரோக்ர்யாம் ,

Mediterranean diet may decrease risk of prostate cancer progression for men on active surveillance


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Mediterranean diet may decrease risk of prostate cancer progression for men on active surveillance
In a study to examine a Mediterranean diet in relation to prostate cancer progression in men on active surveillance, researchers from The University of Texas MD Anderson Cancer Center found that men with localized prostate cancer who reported a baseline dietary pattern that more closely follows the key principles of a Mediterranean-style diet fared better over the course of their disease.
“Men with prostate cancer are motivated to find a way to impact the advancement of their disease and improve their quality of life,” said Justin Gregg, M.D., assistant professor of Urology and lead author of the study, published today in Cancer. “A Mediterranean diet is non-invasive, good for overall health and, as shown by this study, has the potential to effect the progression of their cancer.” ....

United States , Carrie Daniel Macdougall , Justin Gregg , Research Training Award For Cancer Prevention , Training Program In Integrative Epidemiology , University Of Texas Md Anderson Cancer Center , National Cancer Institute Center Support Grant , Cancer Prevention Research Institute Of Texas , Cancer Center , African American , Research Training Award , Cancer Prevention Post Graduate Training Program , Integrative Epidemiology , Cancer Prevention , Research Institute , ஒன்றுபட்டது மாநிலங்களில் , கேரி டேனியல் மக்டூகல் , ஜஸ்டின் க்ரெக் , ஆராய்ச்சி பயிற்சி விருது க்கு புற்றுநோய் ப்ரெவெந்ஶந் , பயிற்சி ப்ரோக்ர்யாம் இல் ஒருங்கிணைந்த தொற்றுநோய் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , தேசிய புற்றுநோய் நிறுவனம் மையம் ஆதரவு மானியம் , புற்றுநோய் ப்ரெவெந்ஶந் ஆராய்ச்சி நிறுவனம் ஆஃப் டெக்சாஸ் , புற்றுநோய் மையம் , ஆராய்ச்சி பயிற்சி விருது , புற்றுநோய் ப்ரெவெந்ஶந் போஸ்ட் பட்டதாரி பயிற்சி ப்ரோக்ர்யாம் ,

Proteogenomics helps treat certain squamous cell carcinomas


Date Time
Proteogenomics helps treat certain squamous cell carcinomas
Proteogenomic analysis may offer new insight into matching cancer patients with an effective therapy for their particular cancer. A new study identifies three molecular subtypes in head and neck squamous cell carcinoma (HNSCC) that could be used to better determine appropriate treatment. The research led by Baylor College of Medicine, Johns Hopkins University and the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) is published in the journal Cancer Cell.
Researchers profiled proteins, phosphosites and signaling pathways in 108 human papillomavirus-negative HNSCC tumors in order to understand how genetic aberrations drive tumor behavior and response to therapies. Currently, there are a few FDA-approved therapies for HNSCC, including an epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) inhibitor and two PD-1 inhibitors, but response rates are moderate. ....

Danielw Chan , Bing Zhang , Johns Hopkins University , Mcnair Medical Institute , National Cancer Institute , Janice Mcnair Foundation , Translational Breast Cancer Research Training Program , Clinical Proteomic Tumor Analysis Consortium , Johns Hopkins University School Of Medicine , Cancer Prevention Research Institute Of Texas , Sue Smith Breast Center , Department Of Molecular , Danl Duncan Comprehensive Cancer Center , Cancer Prevention Institute Of Texas , Baylor College Of Medicine , Baylor College , Human Genetics , Cancer Prevention , Research Institute , Mcnair Scholar , Biomarker Discovery , Johns Hopkins University School , Cancer Prevention Institute , Janice Mcnair , பிங் ஜாங் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் ,

Allterum Therapeutics completes Series Seed offering, builds team with addition of Philip Breitfeld as Chief Medical Officer


Allterum Therapeutics completes Series Seed offering, builds team with addition of Philip Breitfeld as Chief Medical Officer
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HOUSTON, Dec. 17, 2020 /PRNewswire/  Allterum Therapeutics, Inc. completed its $1.8 million Series Seed offering to members of the FanninDirect
SM investor group.  Allterum is developing a novel immunotherapy for treatment of IL7R-expressing cancers, including difficult to treat cases of pediatric acute lymphoblastic leukemia (ALL), a program which has received both Orphan Drug and Rare Pediatric Disease Designations from FDA. The company will use the proceeds for its pre-clinical antibody manufacturing and toxicology work and to continue to build the management team. ....

United States , Serena Miggins , Philipp Breitfeld , Product Development , National Cancer Institute , Eric Schafer Baylor College Of Medicine , Therapeutic Centers Of Excellence , Allterum Therapeutics Inc , Cancer Prevention Research Institute Of Texas , Allterum Therapeutics , Series Seed , Orphan Drug , Rare Pediatric Disease Designations , Global Vice President , Therapeutic Centers , Chief Medical , Scott Durum , Atul Varadhachary , Allterum President , Therapeutics Advances , Childhood Leukemia , Eric Schafer , Baylor College , Texas Children , Susan Rheingold , Investigational New Drug ,