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KIPA shows promise in predicting chemotherapy response in triple negative breast cancer

Researchers at Baylor College of Medicine and collaborating institutions are developing a strategy to predict the response of triple negative breast cancer (TNBC) to chemotherapy, which would be a valuable tool for physicians deciding on the treatment with better probability of success on an individual basis. ....

United States , Junkai Wang , Matthewv Holt , Mothaffarf Rimawi , Alexanderb Saltzman , Beom Jun Kim , Danielle Ellis , Ralph Eads , Danl Duncan , Meenakshi Anurag , Ericj Jaehnig , Folusoo Ademuyiwa , Anna Malovannaya , Matthew Ellis , Researchers At Baylor College Of Medicine , Sue Smith Breast Center At Baylor , Sue Smith Breast Center , Mcnair Medical Institute , Janice Mcnair Foundation , Clinical Proteomic Tumor Analysis Consortium , Washington University School Of Medicine , Danl Duncan Comprehensive Cancer Center Award , Baylor College Of Medicine , American Association For Cancer Research , Developmental Research , Siteman Comprehensive Cancer Center ,

KIPA May Predict Chemotherapy Response in Breast Cancer

KIPA May Predict Chemotherapy Response in Breast Cancer
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Proteogenomics offers insight to treating head and neck squamous cell carcinoma

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HOUSTON - (Jan. 7, 2021) - Proteogenomic analysis may offer new insight into matching cancer patients with an effective therapy for their particular cancer. A new study identifies three molecular subtypes in head and neck squamous cell carcinoma (HNSCC) that could be used to better determine appropriate treatment. The research led by Baylor College of Medicine, Johns Hopkins University and the National Cancer Institute s Clinical Proteomic Tumor Analysis Consortium (CPTAC) is published in the journal
Cancer Cell.
Researchers profiled proteins, phosphosites and signaling pathways in 108 human papillomavirus-negative HNSCC tumors in order to understand how genetic aberrations drive tumor behavior and response to therapies. Currently, there are a few FDA-approved therapies for HNSCC, including an epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) inhibitor and two PD-1 inhibitors, but response rates are moderate. In this study, researchers aimed t ....

Baylor College Of Medicine , United States , Danielw Chan , Bing Zhang , Johns Hopkins University , Mcnair Medical Institute , National Cancer Institute , Janice Mcnair Foundation , Translational Breast Cancer Research Training Program , Clinical Proteomic Tumor Analysis Consortium , Johns Hopkins University School Of Medicine , Cancer Prevention Research Institute Of Texas , Sue Smith Breast Center , Department Of Molecular , Danl Duncan Comprehensive Cancer Center , Cancer Prevention Institute Of Texas , Baylor College , Human Genetics , Cancer Prevention , Research Institute , Mcnair Scholar , Biomarker Discovery , Johns Hopkins University School , Cancer Prevention Institute , Janice Mcnair , பேலர் கல்லூரி ஆஃப் மருந்து ,

Researchers create comprehensive database of head and neck cancers

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In what is believed to be the most comprehensive molecular characterization to date of the most common type of head and neck cancer, researchers from the Johns Hopkins departments of pathology and oncology, the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine, and 18 other centers around the U.S. and Poland have clarified the contribution of key cancer-associated genes, proteins and signaling pathways in these cancers, while proposing possible new treatment avenues.
Their deep-dive investigation of HPV-negative head and neck squamous cell carcinomas (HNSCCs), described in the Jan. 7 issue of the journal
Cancer Cell, involved tumors from 108 patients who had not yet received cancer treatment, and 66 samples of healthy tissue surrounding the tumors. The study systematically catalogued HPV-negative HNSCC-associated proteins, phosphosites (areas where they are modified by phosphate groups) and signaling pathways, fi ....

United States , New York , Johns Hopkins University , Baylor College Of Medicine , International Institute , San Francisco , Davidj Clark , Michael Schnaubelt , Jiang Qian , Daniel Chan , Hui Zhang , Liwei Cao , Qing Kay Li , Jianbo Pan , Yuefan Wang , Johns Hopkins , Kyung Cho , Rodrigo Vargas Eguez , Zhen Zhang , Lijun Chen , National Cancer Institute , Esac Inc , Translational Breast Cancer Research Training Program , Sylvester Comprehensive Cancer Center , Pomeranian Medical University , University Of Medical Sciences ,

Proteogenomics helps treat certain squamous cell carcinomas

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Proteogenomics helps treat certain squamous cell carcinomas
Proteogenomic analysis may offer new insight into matching cancer patients with an effective therapy for their particular cancer. A new study identifies three molecular subtypes in head and neck squamous cell carcinoma (HNSCC) that could be used to better determine appropriate treatment. The research led by Baylor College of Medicine, Johns Hopkins University and the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) is published in the journal Cancer Cell.
Researchers profiled proteins, phosphosites and signaling pathways in 108 human papillomavirus-negative HNSCC tumors in order to understand how genetic aberrations drive tumor behavior and response to therapies. Currently, there are a few FDA-approved therapies for HNSCC, including an epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) inhibitor and two PD-1 inhibitors, but response rates are moderate. ....

Danielw Chan , Bing Zhang , Johns Hopkins University , Mcnair Medical Institute , National Cancer Institute , Janice Mcnair Foundation , Translational Breast Cancer Research Training Program , Clinical Proteomic Tumor Analysis Consortium , Johns Hopkins University School Of Medicine , Cancer Prevention Research Institute Of Texas , Sue Smith Breast Center , Department Of Molecular , Danl Duncan Comprehensive Cancer Center , Cancer Prevention Institute Of Texas , Baylor College Of Medicine , Baylor College , Human Genetics , Cancer Prevention , Research Institute , Mcnair Scholar , Biomarker Discovery , Johns Hopkins University School , Cancer Prevention Institute , Janice Mcnair , பிங் ஜாங் , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் ,