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Closures in both directions are planned from the 10 Freeway to Exposition Boulevard. It's all to demolish the 21st Street bridge no longer in use.
The 110 Freeway closure near downtown L.A. is expected to impact traffic for motorists traveling through the area this weekend.
The 10 Freeway closure in downtown Los Angeles is also affecting rideshare drivers who depend on freeways to make their living.
The fire that engulfed the large storage yard burnt several vehicles parked nearby. Officials are assessing the damage caused by the blaze, before allowing traffic movement.
The 10 Freeway was reopened in Upland on Saturday morning, more than 12 hours after a California Highway Patrol officer shot a man who authorities said was armed with a knife.