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Without Hopkins, Arizona will rely on pass-catchers A.J. Green, Christian Kirk, Rondale Moore and Zach Ertz as well as running back James Conner.
It's been a wild nine days for the Cardinals' newest tight end, who caught three passes for 66 yards, including a 47-yard TD in his Arizona debut.
Arizona's scheme isn't much different from a year ago, but complementary players such as A.J. Green and Rondale Moore have made it more balanced.
Kliff Kingsbury called the running plan designed by Sean Kugler, Arizona's run game coordinator and offensive line coach, "tremendous."