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C-to-G Base Editor Developed by Singapore Genome Institute
March 12, 2021
Source: CIPhotos / iStock / Getty Images Plus
A C-to-G Base Editor (CGBE), using CRISPR, has been developed by a team of researchers from the Agency for Science, Technology and Research’s (A STAR) Genome Institute of Singapore (GIS). This advance opens up treatment options for approximately 40% of the single-base substitutions associated with human diseases such as cystic fibrosis, cardiovascular diseases, musculoskeletal diseases, and neurological disorders.
One in seventeen people in the world suffers from some type of genetic disorder. Mutations responsible for these disorders can be caused by multiple mutagens – from sunlight to spontaneous errors. The most common mutation by far is the single-based substitution, in which a single-base in the DNA (such as G) is replaced by another base (such as C). ....

Kwei Leong , Agency For Science , Genome Institute Of Singapore , A Base Editor , Senior Research Scientist , Getty Images , C Tog Base Editor , Genome Institute , Nature Communications On , Executive Director , வெய் லியோங் , மரபணு நிறுவனம் ஆஃப் சிங்கப்பூர் , மூத்தவர் ஆராய்ச்சி விஞ்ஞானி , கெட்டி படங்கள் , மரபணு நிறுவனம் , இயற்கை தகவல்தொடர்புகள் ஆன் , நிர்வாகி இயக்குனர் ,