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C-to-G Base Editor Developed by Singapore Genome Institute


C-to-G Base Editor Developed by Singapore Genome Institute
March 12, 2021
Source: CIPhotos / iStock / Getty Images Plus
A C-to-G Base Editor (CGBE), using CRISPR, has been developed by a team of researchers from the Agency for Science, Technology and Research’s (A STAR) Genome Institute of Singapore (GIS). This advance opens up treatment options for approximately 40% of the single-base substitutions associated with human diseases such as cystic fibrosis, cardiovascular diseases, musculoskeletal diseases, and neurological disorders.
One in seventeen people in the world suffers from some type of genetic disorder. Mutations responsible for these disorders can be caused by multiple mutagens – from sunlight to spontaneous errors. The most common mutation by far is the single-based substitution, in which a single-base in the DNA (such as G) is replaced by another base (such as C). ....

Kwei Leong , Agency For Science , Genome Institute Of Singapore , A Base Editor , Senior Research Scientist , Getty Images , C Tog Base Editor , Genome Institute , Nature Communications On , Executive Director , வெய் லியோங் , மரபணு நிறுவனம் ஆஃப் சிங்கப்பூர் , மூத்தவர் ஆராய்ச்சி விஞ்ஞானி , கெட்டி படங்கள் , மரபணு நிறுவனம் , இயற்கை தகவல்தொடர்புகள் ஆன் , நிர்வாகி இயக்குனர் ,

Novel CRISPR-based gene editor developed to correct mutations that cause genetic disorders


Novel CRISPR-based gene editor developed to correct mutations that cause genetic disorders
A team of researchers from the Agency for Science, Technology and Research s (A STAR) Genome Institute of Singapore (GIS) have developed a CRISPR-based gene editor, C-to-G Base Editor (CGBE), to correct mutations that cause genetic disorders. Their research was published in
Nature Communications on 2 March 2021.
One in seventeen people in the world suffers from some type of genetic disorder. Chances are, you or someone you know - a relative, friend, or colleague - is one of approximately 450 million people affected worldwide. Mutations responsible for these disorders can be caused by multiple mutagens - from sunlight to spontaneous errors in your cells. The most common mutation by far is the single-based substitution, in which a single-base in the DNA (such as G) is replaced by another base (such as C). Countless cystic fibrosis patients worldwide have C instead of G, leading to ....

Kwei Leong , Emily Henderson , Agency For Science , Genome Institute Of Singapore , Nature Communications , Senior Research Scientist , Genome Institute , C Tog Base Editor , Chew Wei Leong , Young Scientist Award , Patrick Tan , Executive Director , Cystic Fibrosis , Genetic Disorder , வெய் லியோங் , எமிலி ஹென்டர்சன் , மரபணு நிறுவனம் ஆஃப் சிங்கப்பூர் , இயற்கை தகவல்தொடர்புகள் , மூத்தவர் ஆராய்ச்சி விஞ்ஞானி , மரபணு நிறுவனம் , மெல் வெய் லியோங் , இளம் விஞ்ஞானி விருது , பேட்ரிக் பழுப்பு , நிர்வாகி இயக்குனர் , சிஸ்டிக் ஃபைப்ரோஸிஸ் , ஜெநெடிக் கோளாறு ,

From smart clothing to cancer treatments, young researchers' work wins recognition


The Straits Times
From smart clothing to cancer treatments, young researchers work wins recognition
Young Scientist Award recipient Tan Si Hui, 35, was part of a team which made a key discovery that identifies and isolates stem cells leading to stomach cancer.PHOTO: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
https://str.sg/JR34
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National University Of Singapore , Singapore General , Kwei Leong , Si Hui , Chan Chun Sing , Agency For Science , Institute For Health Innovation , Singapore National Academy Of Science , Researcha Star , A Star Genome Institute Of Singapore , Young Scientist Award , Industry Minister Chan Chun Sing , Singapore National Academy , National University , Health Innovation , Chew Wei Leong , Genome Institute , Tan Si Hui , Cargene Therapeutics , தேசிய பல்கலைக்கழகம் ஆஃப் சிங்கப்பூர் , சிங்கப்பூர் ஜநரல் , வெய் லியோங் , சி ஹுய் , சான் சுன் பாட , நிறுவனம் க்கு ஆரோக்கியம் கண்டுபிடிப்பு , சிங்கப்பூர் தேசிய கலைக்கழகம் ஆஃப் அறிவியல் ,