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Placental Hormone Insufficiency Could Negatively Impact a Child's Brain Development

Decreased levels of allopregnanolone (ALLO) in the placenta can result in autistic-like behavior in male children. The reduction in the levels of the placental hormones triggered abnormalities in the cerebellum and changes in myelin sheaths. ....

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Premature birth disrupts Purkinje cell function, resulting in locomotor learning deficits

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In the United States, one in 10 babies are born too soon, resulting in complications that can affect their locomotor development and influence such simple tasks as balance, walking and standing later in life. A new peer-reviewed study by Children s National Hospital, published in the
Proceedings of the National Academy of Sciences of the United States of America (
PNAS), explores exactly what neural circuitry of the cerebellum is affected due to complications that occur around the time of birth causing these learning deficits, and finds a specific type of neurons Purkinje cells to play a central role.
Up until now, there has been a sparsity of techniques available to measure neuronal activity during locomotor learning tasks that engage the cerebellum. To surmount this challenge, Children s National used a multidisciplinary approach, bringing together a team of neuroscientists with neonatologists who leveraged their joint expertise to devise a novel ....

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