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New preclinical research, published in Nature, suggests a new avenue for Alzheimer’s disease (AD) treatment, through restoring lymphatic flow in the brain

Neurogene in tie up with university to advance gene therapy technologies New York based, Neurogene, has announced a research collaboration with the University of Edinburgh for the development of a multiple-platform approach to diseases not addressable by conventional gene therapy. However, the partners were not willing to disclose, as of today, which diseases exactly are being targeted under this alliance. The collaborative project combines Neurogene’s manufacturing and drug development capabilities with the University of Edinburgh’s novel platform and neurodev...

New antibody discovery platform could help accelerate CAR-T therapeutic development In a paper published in the Journal of Biological Chemistry​​​, OXGENE scientists used the self-labelling integral membrane (SLIM) protein discovery system to identify a panel of novel antibodies against the oncogenic target epithelial cell adhesion molecule, which remained in its native configuration within the cell membrane. They said they were able to further demonstrate the functionality of these antibodies in killing cancer cells, when used as a targeting domain of CAR-T cells, thereby “validatin...