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Is Precigen's platform set to transform the field of CAR T cell therapies?

Precigen claims breakthroughs in CAR T cell therapy manufacturing that will eventually allow cancer centers to enable treatments earlier and at a lower cost.
Chimeric antigen receptor (CAR) T cell therapy continues to change the cancer treatment paradigm, with four therapies, to date, approved in the US. While opportunities continue to emerge for new cancer targets, CAR T treatments, up to this point, are, however, associated with some major challenges.
Conventional CAR T cell therapies have shown remarkable responses in patients with Hematologic B cell cancer but they require intensive manufacturing, and their expense has also limited patient access to these novel precision medicines, says Dr Helen Sabzevari, CEO of Precigen. ....

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Scientific breakthroughs, approvals: Latest CAR T-cell therapy related developments

Scientific breakthroughs, approvals: Latest CAR T-cell therapy related developments
From new research offering promise for children s cancer to FDA registrations, we track the progress made in the past few weeks in terms of advancing CAR T-cell therapy in a number of markets.
Novartis on Friday [February 12] reported that it had received approval from Australian regulatory agency, Therapeutic Goods Administration (TGA), for Cell Therapies to manufacture and supply its CAR-T therapies commercially for eligible patients in that market.
The Cell Therapies manufacturing facility in the Peter MacCallum Cancer Center in Melbourne is now the first and only approved commercial manufacturing site for CAR T-cell therapies in Australia. ....

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AbbVie and Caribou partner on CAR-T cell therapy development

AbbVie and Caribou Biosciences have entered into a collaboration and license agreement for the research and development of chimeric antigen receptor (CAR)-T cell therapeutics. ....

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Rexgenero has been renamed Ixaka

Previously Rexgenero Ltd, a UK-based company developing cell therapies to treat serious diseases such as cancer and CLTI, the launch of Ixaka Ltd follows the integration of its nanoparticle gene therapy business in France and a shareholder restructuring.
The company reported that additional financing from existing shareholders, to the tune of over £40m (US$54.1m), will accelerate its proprietary multi-cell and targeted nanoparticle technologies.
Asked why there was a need for a company name change, Joe Dupere, Ixaka CEO, told BioPharma-Reporter:
Ixaka has offices in London, UK with R&D and manufacturing operations in Seville, Spain and Paris, France and additional manufacturing capability in Frankfurt, Germany. ....

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New antibody discovery platform could help accelerate CAR-T therapeutic development

New antibody discovery platform could help accelerate CAR-T therapeutic development
In a paper published in the
Journal of Biological Chemistry, OXGENE scientists used the self-labelling integral membrane (SLIM) protein discovery system to identify a panel of novel antibodies against the oncogenic target epithelial cell adhesion molecule, which remained in its native configuration within the cell membrane.
They said they were able to further demonstrate the functionality of these antibodies in killing cancer cells, when used as a targeting domain of CAR-T cells, thereby “validating the potential of this technology for the discovery of new CAR-T or antibody therapeutics.”
Dr Nathan Robertson, group leader of OXGENE’s antibody discovery team said: “ ....

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