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Study estimates impact of amino acid changes on SARS-CoV-2 infection New research led by Costas D. Maranas from The Pennsylvania State University predicts amino acid changes to the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein would negatively impact binding affinity and subsequent infection into human cells. Their results were derived from a novel two-step procedure called neural network molecular mechanics/Poisson-Boltzmann surface area (NN_MM-GBSA) that calculated binding energy from receptor-binding domain variants to human angio...

Researchers in India have gathered and presented a large body of evidence highlight quercetin – a flavonoid molecule found in many common fruits and vegetables – may be developed into drug therapies used to combat COVID-19.

Novel protein construct prevents lethal COVID-19 in mice Researchers in the United States have developed a novel protein that prevented lethal disease among mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19). The team engineered a soluble, short, and dimeric version of the native host cell receptor that is bound by a surface structure on SARS-CoV-2 called spike during the initial stage of the infection process. The team – from the Feinberg School of Medicine in Chicago, the University of Chicago, and ...

Researchers explore difference in reactions to SARS-CoV-2 infection between children and adults The coronavirus disease 2019 (COVID-19) pandemic has claimed over 2.67 million lives in less than a year and a half. However, it is uncommon in children, with less than 2% of the cases being in individuals below the age of 19. Most of these are of mild severity, with the clinical features of severe COVID-19 being rare in this age group. A new and timely study, which was released on the medRxiv* preprint server, explores the differences in the response to severe acute respiratory syndrome coronavir...

New research proposes innovative antibody-based treatment to prevent SARS-CoV-2 viral entry A brief report by researchers at the University of Virginia, USA, proposes using an antibody-based treatment with a plug-and-play strategy to inhibit the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to invade human cells. The spike protein of SARS-CoV-2 binds with angiotensin-converting enzyme 2 (ACE2) receptors found on human cells, allowing it to gain entry and take over the cell’s machinery for replication. The treatment results show it works by blocking the host proteas...