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Researchers found a small molecule that inhibits different virus proteins and significantly reduces infection in cells. Combined with the antiviral remdesivir, its potency increases significantly, suggesting it may be a potential antiviral candidate for the treatment of COVID-19.
Early antibody response predicts COVID-19 outcome Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus behind the coronavirus disease 2019 (COVID-19) pandemic, has claimed over 2.54 million lives so far and affected more than 114 million people globally. In the U.S. alone, more than 516,000 deaths are attributed to the virus. Neutralizing antibodies targeting the SARS-CoV-2 spike protein are the most widely used candidates for developing vaccines and therapeutics. So far, there have been three Emergency Use Authorizations by the U.S. Food and Drug Administration...
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Researchers have investigated the effectiveness of a bioengineered miniprotein in protecting against SARS-CoV-2 infection in vivo. The researchers evaluated the miniprotein, LCB1, against SARS-CoV-2-mediated lung disease in human ACE2-expressing transgenic mice.
Researchers at the New York State Department of Health in the United States have said concerning mutations within the B.1.526 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has recently become prevalent in New York State warrant further monitoring.
New research suggests Syrian golden hamsters could be a potentially useful preclinical model for testing vaccine immunity against the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.17 and B.1.351 variant.